A Comprehensive Review of Recent Studies on Matrix Tablets for Drug Delivery with Oral Controlled Release

Author: Dipak P. Kardile, Pravin B. Awate, Vishwas C. Bhagat, Ratan S. Birajdar, Rajkumar V. Shete, Suchita S. Lathi, Bhagyashri R. Mathdevru, Onkar P. Pawar and Rani M. Mhetre

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Abstract

Developing oral controlled release matrix tablet with constant release rate has always been a challenge to pharmaceutical technologist. The main challenges to oral drug delivery systems are to deliver a drug at therapeutically effective rate to desirable site, modulation of GI transit time and minimization of first pass elimination. Control release dosage form provides better maintenance of optimal and effective drug level for prolonged duration with less dosing frequency and side effects. Oral drug delivery has traditionally been the most popular mode of administration when compared to other options. Matrix tablets are the most common method for modifying a drug's release profile. By protecting the active ingredient from hydrolysis and degradation and reducing dose frequency, controlled release matrix tablets increase patient compliance. Hydrophobic polymer-based matrices release drugs more slowly than hydrophilic polymer-based matrices do. Diffusion or dissolving control mechanism ensures that medications are released from controlled release matrix tablets at a controlled and predictable rate. In order to create oral controlled drug delivery dosage forms, hydrophilic polymer matrix systems are commonly used due to their adaptability and capacity to provide a desired drug release profile. In this formulation polymer (The hydrophilic and hydrophobic polymers) used as release rate retardants, that’s why it controls drug blood level with uniform therapeutic level and avoid fluctuation thus prevent local or systemic adverse reactions.

Keywords

Controlled release, hydrolysis, dissolution, diffusion, erosion, hydrophobic polymer, hydrophilic polymer, and kinetics of drug release

Conclusion

Oral release of control one of the convenient, safe, and effective dosing forms is the matrix tablet. Different polymers can be used to build various sorts of controlled release systems. The numerous biological and physicochemical characteristics of the medication and excipients are necessary for the successful production of the matrix tablet system. The distinct benefits of matrix tablets make them a compelling alternative for an oral controlled medication delivery system. Many medications can be given in ways that not only increase safety and efficacy but, in some circumstances, allow for novel and more effective therapies by using matrix tablets as an oral controlled release formulation. Different matrices, polymers, and release mechanisms from the matrix tablets have been discussed in this paper. Matrix tablets have discrete advantages which make them interesting candidate for oral controlled drug delivery system. Matrix tablets are helpful in increasing the efficiency of dose, increasing patient compliance. The problem of high cost of production, which was the disadvantage in early days, has been solved with improvement in technology. Using matrix tablet as oral controlled release formulation, many drugs, can be delivered in ways that not only improves safety and efficacy but, in some cases, permit new and more effective therapies.

References

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How to cite this article

Dipak P. Kardile, Pravin B. Awate, Vishwas C. Bhagat, Ratan S. Birajdar, Rajkumar V. Shete, Suchita S. Lathi, Bhagyashri R. Mathdevru, Onkar P. Pawar and Rani M. Mhetre (2023). A Comprehensive Review of Recent Studies on Matrix Tablets for Drug Delivery with Oral Controlled Release. Biological Forum – An International Journal, 15(4): 789-798.