A Review on – Liposomes as a Novel Drug Delivery System: Marketed Products and Future Perspectives

Author: Deepak P. Kardile, Pravin B. Awate, Vishwas C. Bhagat, Aarti Y. Rajput, Rajkumar V. Shete, Mitali A. Aher, Priya R. Patil and Shraddha S. Pawar

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Abstract

Liposomes are a drug delivery system that is adaptable and optimistic. The benefits of liposomes over other drug delivery systems include site-targeting, prolonged or controlled release, protection of drugs from degradation and clearance, higher therapeutic effects, and fewer toxic adverse effects. As effective drug carriers in pre-clinical and clinical studies, liposomes provide a wide range of benefits and uses. Additionally, issues pertaining to liposomal stabilization, efficient targeting techniques, and some of their drawbacks were discussed. Formulation of liposomes has enabled the modification of drug biodistribution of many drugs, hence improving the therapeutic properties of those compounds. In conclusion, this study aims to investigate the liposomes currently on the market that are used as a drug delivery method in various therapeutic uses.

Keywords

Liposomes, Drug delivery, Liposome Production, Applications, Commercialised products

Conclusion

Liposomes are one of the unique drug delivery systems that played a significant role in the formulation of potent drugs, which can be of potential use in controlling and targeting drug delivery and improving their therapeutics. Drugs of both categories (hydrophilic/ lipophilic) are easily embedded in the liposomes. The liposomal formulation's effectiveness relies on its capacity to transport the molecules to the desired site over a lengthy duration of time, whereas minimizing the drug's adverse effects. The phospholipid bilayers contain the medicines, which are predicted to diffuse out of the bilayer gradually. When the development of liposomal drug therapy delivery methods, a number of variables, including drug quantity, the ratio of drug to lipid, capsule effectiveness, and in vivo drug release, must be taken into consideration. Liposomes are administrated orally, parenterally, and topically as well as used in cosmetic and hair technologies, sustained release formulations, diagnostic purposes, and as good carriers in gene delivery various drugs with liposomal delivery systems have been approved. Nowadays liposomes are used as versatile carriers for targeted delivery of drug. The liposomal technique is used effectively to enhance the pharmacokinetics and therapeutic effectiveness while concurrently lowering the toxicity of different extremely potent medicines.

References

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How to cite this article

Deepak P. Kardile, Pravin B. Awate, Vishwas C. Bhagat, Aarti Y. Rajput, Rajkumar V. Shete, Mitali A. Aher, Priya R. Patil and Shraddha S. Pawar (2023). A Review on – Liposomes as a Novel Drug Delivery System: Marketed Products and Future Perspectives. Biological Forum – An International Journal, 15(5): 33-38.