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A Study Investigating the Consequences of Red Grape Seed Extract (RGSE) on D-galactose-induced Memory Impairment in Albino Male Rats (WISTAR Stain)

Author: H. Rama Subba Reddy and V. Uday Kiran

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Abstract

Objective: To study the effect of RGSE on memory impairment of D-Galactose induced in albino male rats (Wister stain). Methodology: The progressive destruction of memory and learning in individuals with Alzheimer's disease (AD) eventually results in a conclusive diagnosis. The main goal of this study was to determine how Red Grape Seed Extract (RGSE) affected the male albino rats' brains following their exposure to D-galactose-induced memory impairment. Male rats were split into two groups (control and RGSE treated) and given oral doses of both alcoholic and aqueous extracts of Vitis vinifera’s Red Grape Seed Extract for a duration of 30 days. Rats that were treated with RGSE (100 mg/kg) orally gavaged for 30 days, whereas control rats were given normal saline. They used the Morris Water Maze for training. Results: My hands-on experience with this test demonstrated that giving red grape seed extract to albino male rats enhances their performance in the water maze with regard to memory retention. Conclusion: We discovered that RGSE had a notable cognitive-enhancing impact based on the outcomes of the Morris water maze tests conducted with albino male rats. William’s maze and retention memory show improved memory and learning

Keywords

RGSE, Memory, D-Galactose, Water maze, Albino Rats

Conclusion

Red grape seed extract (RGSE) treatment improved both memory deficit and particular memory in rats with Alzheimer's disease (AD). Thus, our results support the potential therapeutic uses of RGSE to prevent neurodegenerative illnesses. This review clearly shows that RGSE is important for improving all energy metabolisms in rats given an AD, as well as for increasing the amount of neurotransmitters in the brain system

References

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How to cite this article

H. Rama Subba Reddy and V. Uday Kiran (2023). A Study Investigating the Consequences of Red Grape Seed Extract (RGSE) on D-galactose-induced Memory Impairment in Albino Male Rats (WISTAR Stain). Biological Forum – An International Journal, 15(7): 397-400.