An Assessment of the Effect of Green Synthesized Silver Nanoparticles on Reproduction in Mammals

Author: Ashish Kumar Kansotiya, Suman Kumari, Prity Yadav, Neha Bharti, Nitesh Kumar Poddar and Pratap Chand Mali

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Abstract

This study investigates the reproductive toxicity of rats treated with silver nanoparticles of leaves extract of P. roxburghii. Green chemistry was employed for the synthesis of AgNPs using leaf extracts of P. roxburghii. The size, shape, morphology, and stability of resultant AgNPs were investigated by UV–Vis Spectroscopy, FTIR, SEM. Suspension of SNPs of P. roxburghii leaves were administered orally to albino male rats for 60 days, to determine their effects on the reproductive parameters of the testes. The animals were divided into 5 groups A, B, C, D, and E each group having 10 rats. Group A was control group, and Groups B, C, D were administered 10mg/kg, 20mg/kg, and 30mg/kg b.wt/day respectively of Silver nanoparticles of leaves extract. Group E is recovery group animals of this group treated with medium dose and kept for recovery for 30 days. The UV–Vis spectra showed specific Surface Plasmon Resonance (SPR) absorption peaks between 411 nm and 429 nm which revealed the formation of AgNPs during the synthesis. The nanoparticles synthesis was further confirmed by FTIR and SEM analysis. The results showed that the weight of testes and other reproductive organs were significantly reduced in groups B, C, and D when compared with control. The decrease in the number of sperm cells and sperm motility was greatest in the group D (dose of 30 mg/kg b.wt). Histopathological findings indicated degenerative changes in testes. From these findings, it is concluded that silver nanoparticles of leaves extract of P. roxburghii is quite effective in reversible suppression of male fertility

Keywords

Reproductive toxicity, Silver nanoparticles, P. roxburghii, Sperm motility

Conclusion

From the results of current investigation, it can be concluded that SNPs of leaves extract of P. roxburghii is effective in the terms of male contraceptives due to their fertility regulative. The effects may have an inhibitory influence on surrounding environment of testis which may be responsible for the decline in sperm density and motility, leading to changes in spermatogenesis

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How to cite this article

Ashish Kumar Kansotiya, Suman Kumari, Prity Yadav, Neha Bharti, Nitesh Kumar Poddar and Pratap Chand Mali (2024). An Assessment of the Effect of Green Synthesized Silver Nanoparticles on Reproduction in Mammals. Biological Forum – An International Journal, 16(11): 32-38.