Anti-inflammatory Action of Polypore Mushroom Bondarzewia berkeleyi in Western Ghats of Kanyakumari District, Tamil Nadu

Author: S. Sreedevi and G. Hepzibah Beulah

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Abstract

Mushrooms have been utilised for both food and medicinal from the beginning of human history. The ancient Greeks and Romans both held the firm idea that mushrooms, often called "Food of the Gods" in the former, would provide a tactical advantage to seasoned soldiers". Mushrooms have long been revered in Chinese culture as a "elixir of life" and a source of nutrition. The goal of the current research was to assess the anti-inflammatory activity of a particular medicinal fungus, Bondarzewia berkeleyi. Lipoxygenase and cyclooxygenase, Nitric oxide synthase, myeloperoxidase were all tested and reported. In Lipoxygenase and cyclooxygenase at the concentration of 100 µl/ml, the inhibitory activity of was 33.55% and 30.41% respectively. Myeloperoxidase at the concentration of 100 µl/ml provided the best inhibitory action, which is dose-dependent. The largest nitric oxide scavenging effect for nitric oxide synthase was shown by mushroom extract, which had a 41.53% efficiency in 50 µl /ml. Recent reports indicate that edible mushroom extracts have beneficial therapeutic and health-promoting effects, especially in diseases associated with inflammation. With certainty, edible mushrooms can be called "superfoods" and are recommended as a valuable component of the daily diet. The aims of this review are to report the different types of bioactive metabolites and their relevant producers, as well as the different mechanisms of action of mushroom compounds as potent anti-inflammatory agents.

Keywords

Mushroom, Bondarzewia berkeleyi, COX, LOX, MPO, anti-inflammatory

Conclusion

In summary, our research showed that the mushroom in concern possessed anti-inflammatory capabilities. This suggests that the mushroom could be considered a functional food with anti-inflammatory qualities. Now that we have a clearer grasp of the biological activity, we must turn our attention to identifying the molecules responsible for it. However, further research is required to learn how exactly these bioactive components and other crucial nutrients affect and interact with one another. To sum up, the aforementioned obstacles must be addressed through further study before macrofungi can be universally recognised as one of the most important biofactories for the manufacturing of anti-inflammatory medications.

References

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How to cite this article

S. Sreedevi and G. Hepzibah Beulah (2023). Anti-inflammatory Action of Polypore Mushroom Bondarzewia berkeleyi in Western Ghats of Kanyakumari District, Tamil Nadu. Biological Forum – An International Journal, 15(5): 1175-1180.