Diabetes is a metabolic disorder characterized by chronic hyperglycemia and alternations in carbohydrate, protein and lipid metabolism with absolute or relative deficiencies in insulin secretion or insulin production. Nilavembu Kudineer (NVK) is a Siddha polyherbal concoction containing nine ingredients. There are very few studies to explore the antidiabetic potential of the NVK formulation and lack of scientific documentation to validate the efficacy of this formulation. Our study aimed to investigate the anti-diabetic activity of NVK in rats with fructose-induced insulin resistance. The total duration of the study was 90 days, and during the induction period (i.e., 60 days/8 weeks) 20% fructose was given to all animals through drinking water and weekly blood glucose and body weight were measured. After 8 weeks animals with blood glucose level more than 135mg/dl were taken for the study and the animals were randomly divided into four groups. The study continued for a period of 4 weeks. Body weight, blood glucose was measured weekly and after experimental period all the animals were sacrificed for biochemical, hematological and histopathological studies. Standard and NVK treated group were found to be reducing the blood glucose, creatinine, WBC and there was increase in body weight, HDL levels, RBC, Hemoglobin, Platelet count, red cell distribution width when compared to negative control group. In silico analysis also reveal sotetsuflavone and hesperidin from NVK possess antidiabetic activity

Anti-diabetic, Nilavembu Kudineer, Fructose, Docking, insulin

The present study is an attempt to investigate the effect of NVK on fructose induced diabetes in rats. The serum glucose, lipid profile, SGOT and SGPT shown to be increased in NVK treated diabetic animals. In the present study the bodyweight, HDL shown to be increased in NVK treated diabetic animals when compared to negation control. The findings of the present investigation suggest that NVK has the potential for its evaluation as an anti-diabetic agent against fructose induced diabetes. Assessment of NVK for its underlying mechanisms will be an interesting topic and requires further study

Meghana K., Shivani E., Premkumar B., Leela Priyanka G.C., Sruthy Jacob, Rabiyamma S. and Syed Hussain Peeran S. (2023). Antidiabetic Effect of Siddha Polyherbal Decoction, Nilavembu Kudineer, in Rats with Fructose-Induced Insulin Resistance. Biological Forum – An International Journal, 15(3a): 40-45