Aquasomes: A Novel Approach in Drug Delivery System for Poorly Water-Soluble Drug

Author: Vishwas C. Bhagat, Pravin B. Awate, Dipak P. Kardile, Nilesh A. Narote, Rajkumar V. Shete and Adinath C. Bhusari

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Abstract

Aquasome are novel drug delivery systems in conventional dosage forms, includes various carrier systems for developed the nanoparticles system. The aquasomes formulation are administered by oral or parenteral route. Bioactive molecules developed in delivery system like protein, hormones, vaccine, antigen, gene bind the specific site. The particle size of aquasome is 60-300 nm range with spherical shape. Structure of aquasomes comprise three layers, assembled with ceramic core coated stabilized by active biomolecules are adsorbed without modification. Carbohydrate coating provide structural stability or protect against dehydration and maintaining the property of surface exposure in targeted delivery of molecules. To enhance dose frequency of aquasomes is challenges of preparation in aquasomes, the slow antigen produces at sustained rate it has proven effective to enhance immunity against covid-19. Pharmaceutical active molecules incorporated to surface by adsorption. The sustained release process, combination of bioactive molecules and targeted molecules are delivered through aquasomes. This review article is focus on revolutionary characterization and application of aquasomes in targeted drug delivery systems.

Keywords

Conventional drug delivery, Aquasomes, carrier system, bioactive molecule, Targeted molecule

Conclusion

The aquasomes deliver shows better biological activity and it has great solubility or enhancing property to the targeted side. The carbohydrate coat is preserving the bioactive molecules or drug interaction in formulation, it has focus on novel drug delivery system for drawbacks related in pharmaceutical agent. The crystalline nature core gives aquasome stability as broad range of molecules and better immunological response in immune system or it carries antigen, insulin or enzyme delivery, blood substitutes in hemoglobin.

References

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How to cite this article

Vishwas C. Bhagat, Pravin B. Awate, Dipak P. Kardile, Nilesh A. Narote, Rajkumar V. Shete and Adinath C. Bhusari (2023). Aquasomes: A Novel Approach in Drug Delivery System for Poorly Water-Soluble Drug. Biological Forum – An International Journal, 15(4): 144-149.