Biological Activity of Curcumin in Inflammatory Diseases and Cancers: A Review

Author: Bahuguna Ankit, Indu Tewari and Sanjay Singh

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Abstract

Curcumin is an active component in Curcuma longa which has derivation from its Rhizome. It is a perennial plant. Curcumin has molecular formula: C21H20O6. It is chemically, 1, 7- bis (4- hydroxy - 3 methoxyphenyl) -1, 6 - heptadine - 3, 5 – diene. It is also termed as- ‘Di feruloyl methane’. It is extensively employed as a herbal drug in treatment of various diseases mainly associated with inflammatory conditions. In this review paper, mechanisms of action of Curcumin of various molecules of inflammation associated pathway has been studied. Also, few clinical trials have been researched up on which throw a light on beneficial effects of Curcumin in inflammatory conditions like- rheumatoid arthritis and malignant conditions such as colorectal carcinomas. Hence, the challenges while performing the review article were to pin-point pharmaceutical benefits of Curcumin within acceptable dosages over various inflammatory diseases and cancerous conditions affecting humans.

Keywords

Curcumin, Curcuma, inflammation, cancer, biological, mediators, chemokines

Conclusion

Curcumin has been seen to target a vast variety of molecular sites or targets as it has significant potential as therapeutic drug in various inflammatory diseases and types of cancer. The significant obstacle in utilization of curcumin in medical therapeutics is its limited bioavailability systemically. Hence, researchers all across the world are investigating large numbers of components of curcumin components and its analogous as they have greater effectiveness and have better absorption capacity. Observed results from different clinical trials have shown promising results. Henceforth, more studies are being conducted in treating inflammatory conditions and various types of cancers.

References

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How to cite this article

Bahuguna Ankit, Indu Tewari and Sanjay Singh (2023). Biological Activity of Curcumin in Inflammatory Diseases and Cancers: A Review. Biological Forum – An International Journal, 15(4): 771-774.