Indexing

Design and Evaluation of Fast Dissolving Tablet Containing Diclofenac Sodium using Caesalpinia pulcherrima Galactomannan as A Natural Superdisintegrant

Author: Thombre N.A., Sonawane S.S., Jadhav A.R., Jogdand R.R., Dhavale S.H., Jadhav V.S., Choudhari S.M. and Raut P.

PDF Download PDF

Abstract

An oral dosage form containing diclofenac sodium prepared by using Caesalpinia pulcherrima galactomannan (CPG) as a natural superdisintegrant. In order to prepare the diclofenac sodium tablet, the direct compression method was used. Superdisintegrant property of this polymer is not yet discovered. Trial batches were taken and by that the final formulation were prepared. Superdisintegrant property 32 factorial design applied at MET with quantity of drug, CPG and lactose as dependent variables. CPG were used as superdisintegrant and lactose were used as directly compressible excipient. The developed tablets underwent testing for hardness, friability, DT, and in vitro drug release. Design Expert 13 described adequately impact of selected variables (CPG and lactose) at various levels for response under study of disintegration and drug release. The optimized batch showed disintegration time 942.00 sec and in vitro drug release between 90.64±0.0023 % The current experimental design study showed that CPG and lactose were effective in developing optimised formulations at low concentrations. It can be inferred from the experimental findings that CPG exhibited superdisintegrant action.

Keywords

Diclofenac sodium, Caesalpinia pulcherrima galactomannan (CPG), Superdisintegrant, Lactose, Direct compression

Conclusion

The present work involves to formulate diclofenac sodium as fast dissolving tablets (FDT) using Caesalpinia pulcherrima galactomannan as a natural superdisintegrant. FDTs containing various incorporating active ingredients were evaluated for effect of various excipients FDTs containing various excipients were evaluated for disintegration and dissolution. The current study claimed as an ideal tool for development of product as per ideal limits.

References

-

How to cite this article

Thombre N.A., Sonawane S.S., Jadhav A.R., Jogdand R.R., Dhavale S.H., Jadhav V.S., Choudhari S.M. and Raut P. (2023). Design and Evaluation of Fast Dissolving Tablet Containing Diclofenac Sodium using Caesalpinia pulcherrima Galactomannan as A Natural Superdisintegrant. Biological Forum – An International Journal, 15(5): 343-350.