Efficacy of Cinnamon in Ameliorating Streptozotocin-induced Diabetic Liver Injury in Rats: Histological and Biochemical Studies

Author: Mona R. Alshathly* , Amal A. E. Ibrahim*,** and Amira H. El-Etriby*

Download PDF

Abstract

Natural herbs are considered beneficial and useful in alternative medicine with increasing research interest on their role in treating diseases. This study was designed to investigate the efficacy of cinnamon as a therapeutic agent for controlling hyperglycaemia and protecting liver tissue in diabetic rats. Experimental animals were divided into treated and untreated groups. Results showed body and liver weights decreased after six weeks of streptozotocin injection. The administration of cinnamon revealed a significant bodyweight increase compared to diabetic untreated group and restored liver enzyme levels as well as a decrease in glucose levels. Histological observation showed marked protection against hepatocytes nuclear and degenerative changes induced by diabetes, which concorded with the biochemical results.

Keywords

Diabetes - Rat Hepatocytes - Liver Functions – Histology – Cinnamon – Metformin

Conclusion

Cinnamon is well known for its antioxidant effect beside its activity in controlling diabetes. Histological supported by biochemical investigation proved its hepatoprotective effect against STZ induced diabetic changes in rat liver. Further studies will be done to identify its exact mechanism regarding controlling blood glucose level and antagonizing oxidative stress impact on liver tissue.

References

-

How to cite this article

Mona R. Alshathly , Amal A. E. Ibrahim, and Amira H. El-Etriby (2018). Efficacy of Cinnamon in Ameliorating Streptozotocin-induced Diabetic Liver Injury in Rats: Histological and Biochemical Studies Biological Forum – An International Journal 10(1): 82