Evaluation of Anti-diabetic and Hypolipidemic Activity of Drypetes roxburghii Roots

Author: Isha Talwar, Satish Kumar Sharma and Kaneez Fatima

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Abstract

Metabolic disorders such as diabetes (higher glucose level) and obesity (hyperlipidemia) is a major cause of cardiovascular disease. Apart from mainstream medications, botanicals serve as a popular treatment to manage these conditions. To evaluate anti-diabetic and hypolipidemic activity of Drypetes roxburghii (DR) root extract in experimental animal models. The roots were extracted using 70% ethanol. Flavonoid and phenolic compound content were quantitatively estimated. Acute oral toxicity of the extract was determined and two doses were selected to evaluate the pharmacological activity. For evaluation of anti-diabetic activity streptozotocin induced diabetes was used as a model and parameters like blood glucose level, liver enzymes, in-vivo oxidative parameters, in-vitro -amylase and -glucosidase level were determined. For evaluation of hypolipidemic activity, high fat diet induced hyperlipidemia was used as a model and parameters like body weight, complete lipid profile and HMG-CoA reductase inhibition was determined. The phenolic content and the flavonoid content was found to be 55.740 g GAE/mg and 142.87 g QE/mg respectively, in crude extract. The extract was found to be safe till 2000 mg/kg BW. The extract at dose 200 mg/kg BW was found to be a potent anti-diabetic and anti-hyperlipidaemic agent. The extract showed potent anti-diabetic and hypolipidemic activity. Ethical concern, selection of statistical test.

Keywords

Drypetes roxburghii, Flavonoid content, Diabetes, hyperlipidemia, streptozotocin high-fat-diet

Conclusion

From the above finding, it can be concluded that Drypetes roxburghii root extract was found to have potent anti-hyperglycemic and anti-hyperlipidemic activity, which may be attributed to the presence of flavonoids and phenolic compounds (potent antioxidants) in it.

References

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How to cite this article

Isha Talwar, Satish Kumar Sharma and Kaneez Fatima (2023). Evaluation of Anti-diabetic and Hypolipidemic Activity of Drypetes roxburghii Roots. Biological Forum – An International Journal, 15(5): 1655-1669.