INTRODUCTION Finger millet was introduced from Ethiopian highlands to India around four thousand years ago as original native (Anon., 2012). India is the primary producer of finger millet, which is primarily grown in the states of Tamil Nadu, Karnataka, Andhra Pradesh, Maharashtra, Uttar Pradesh, Bihar, Orissa and Gujarat. It account together for 98% and 95% of the total production and cultivation area of finger millet in the country (Sonnad, 2005) respectively. Finger millet is having rich calcium source, around 10 folds that of wheat or rice. Unlike wheat and rice that require important inputs in terms of soil fertility and water, millets grow well in dry state as rain-fed crops (Michaelraj and Shanmugam 2013). Generally diseases are the major limitations in production of finger millet. Totally, 25 fungal, 4 viral, 5 bacterial and 6 nematode pathogens have been recorded on this crop (Mundhe, 2005). The most important constraint in the production of finger millet in all the millet-growing regions of the world is blast disease caused by the fungus Magnaporthe oryzae (Magnaporthe oryzae) B. Couch (anamorph: Pyricularia oryzae Cavara); synonym Magnaporthe grisea (Hebert Barr) (Zhang et al., 2016) and causes yield losses around 28 % (Vishwanath and Seetharam 1989), however in a conducive climate it may go higher to 80 - 90 % (Ramappa et al., 2002). The most capable, feasible, eco-friendly and low cost method to control the plant diseases is grow the resistance variety. Patro et al. (2018) understand the inheritance of resistance to Pyricularia grisea by attempts are being made to develop resistance finger millet lines. However, host plant resistance is the key factor to manage the rice blast disease. Pyricularia grisea has breakdown of resistance within few years by develop new pathogenic races causes’ (Ahn, 1994). Thus, attempts have been made to manage blast disease in different crops by using fungicides (Pagani et al., 2014). While, old generation fungicides like carbendazim, ediphenphos etc., were found to be effective against blast diseases however, the advanced and new molecule fungicides spray at the time of incidence was lacking. Considering these facts in view, in vitro studies and field trials were conducted to manage all the three types of blasts (leaf, neck and finger) of finger millet by using new molecule of fungicides. MATERIALS AND METHODS Isolation of Pathogen (Pyricularia grisea). To isolate the pathogens from symptomised parts of the leaves were cut in to 2mm size pieces with sterilized scissors. Those pieces were surface sterilized by using 1% sodium hypochloride for 1 minute, followed by two successive cleaning with sterilized distilled water. Then they were kept in clean sterile petridish containing three layers of moistened blotting paper. The samples were then incubated at 25 to 26°C for one day. From the sporulating lesions on the leaf sample, single conidia were transferred to separate sterilized culture tubes of agar slants. Spreading conidia from the discrete lesions on 4% water agar with the help of aseptic inoculating needle under stereomicroscope to get single spore isolates. Transfer the germinating conidia aseptically to agar plate. The plate was incubated at 25± 2°C for 72-96 hours under incubator. In vitro evaluation of fungicide against finger millet blast. Various chemical groups of eleven fungicides at two different concentrations (0.1 and 0.2%) were tested for their efficacy under in vitro condition against Pyricularia grisea by using poison food technique (Nene and Thapliyal 1979). The fungicides concentrations taken were those of active ingredients present in commercial formulation. The required quantities of each test fungicides were incorporated in a 250 ml conical flask containing 100 ml of molten finger millet leaf extract agar (FLEA) medium so as to get required concentration in per cent (%). The poisoned medium was well shaken and poured in to sterilized petriplates in 20 ml each. On solidification of the medium, the plates were inoculated in the centre by placing 5 mm diameter mycelial disc cut by the help of cork borer from 15 days old actively growing P. grisea grown on FLEA medium. Each concentration of respective fungicide were maintaining three repetitions and incubated at 25±10°C temperature under B.O.D. The observations on mycelia growth of fungus were recorded at 24 hours interval up to full growth reached in control petriplate. Vincent (1927) illustrated the per cent growth inhibition (PGI) of the pathogen over control was worked out by using following formula, PGI = 100 (DC -DT)/ DC Where, PGI = Per cent growth inhibition DC = Average mycelial diameter growth in control plate (mm) DT = Average mycelial diameter growth in fungicide treated plate (mm). Management of Pyricularia grisea under field condition. Based on the results of in vivo studies, the field experiments were conducted during the rabi, 2019 and rabi, 2020 at Centre of Excellence in Millets, Athiyandal (12° 23N, 70°02E, 280 m asl) against Pyricularia grisea. The finger millet variety CO (Ra) 14 was sown with standard plot size of 5 × 3 m, implementing the recommended spacing and dosage of fertilizers. In the present investigation the treatments are framed to test the efficacy of new molecule fungicides (Tebuconazole 50% + Trifloxystrobin 25 W, Tricyclazole + Mancozeb 62% WP, Isoprothiolane 40% EC, Azoxystrobin + Difenconazole, Propiconazole) as it is unique combination of systemic and contact fungicide were tested with standard checks (Tricyclazole 75%WP, Carbendazim 50%WP and Carbendazim + Mancozeb) with bacterial antagonist (Bacillus subtilis) and antibiotics (Kasugamycin, Blasticidin and Aureofunginsol) were used to comparison studies under field condition. The trial is design as randomized block design (RBD) with three replications to find out the management of blast in finger millet under field condition. After observing the leaf blast incidence, treatment spray was carried out and second spray 10-15 days after first spray. The leaf blast (50 DAS), neck blast (Flowering stage) and finger blast (Maturity stage) disease incidence and grain yield were recorded. Blast disease assessment: The occurrences of leaf blast in individual leaves were recorded by using 1–9 scale Standard Evaluation System (SES). The neck blast and finger blast severity (%) were enumerated across all the panicles in each replication and treatment. Total number of infected neck and finger were counted and disease incidence % was worked out by using the following formula as followed in All India Co-ordinated Research Project on Small Millets (AICRP-SM) 27th Annual Group Meeting, 2016 (Patro et al., 2020). Economic appraisal (B:C ratio) of treatments. Economic analyses of each treatment were worked out on input costs and returns basis. Total returns were calculated by marketable yields of grain and fodder obtained in each treatment. The cost of bio-control agent and fungicides used per treatment and spraying cost of fungicides were estimated. The increase in grain and fodder yield over control was assumed to be exclusively due to the treatments effect. For that reason, partial budgeting was used to magnify the profit per hectare for each treatment. The profit was worked by deducting the treatment cost from additional income derived from yield increase above control (Untreated). Costs of land preparation, sowing, weeding, fertilizer application, irrigation and harvesting were incorporated in the partial budgeting. Benefit-cost ratio, was calculated as Statistical analysis of the experiment. The experimental data statistical analysis was carried out by adopting the standard method (Gomez and Gomez, 1984). The spray treatments impact was observed by analysis of variance (ANOVA) of randomized block design (RBD). Data of neck blast and finger blast were arcsine transformed before analysis. RESULTS AND DISCUSSION In vitro studies. The results indicated that Tricyclazole 75%WP @ of 0.1% effectively controlled the Pyricularia grisea mycelial growth to an extent of 76.67% over control. Followed by Tricyclazole + Mancozeb 62%WP @ of 0.1 per cent treatment inhibited the mycelial growth to an extent of 75.56% over control (Table 1). Both treatments are on-bar with each other; however Tricyclazole as the effective component of the fungicide to control the blast pathogen under in vitro condition. The fungicides evaluation under in vitro condition against rice blast pathogen, Pyricularia grisea showed that tricyclazole + tebuconazole (36% SC), tebuconazole 25% SC, hexaconazole 5% EC, zineb 68% + hexaconazole 4% WP and tebuconazole 50% + trifloxystrobin 25% WG inhibited completely the growth of fungus and germination of fungal spores in all concentration (Kavanashree et al., 2019). Neelkanth et al. (2017) revealed that carbendazim, tricyclazole and trifloxystrobulin + tebuconazole of all concentrations were found to be effective against blast pathogen showing 100% inhibition of mycelial growth under in vitro condition. Field studies. In the Active Tillering stage (30-35 DAS), leaf blast incidence occurred in all the plot (up to 8 grade). At the time of incidence the spray treatment were carried out and observations taken on flowering stage or 50 DAS. Among the 13 treatments, including the new molecule of fungicides, Tricyclazole 75%WP (T3 - first spray at the time of disease incidence, second spray 10-15 days later @ 1 g/lit) recorded less incidence of leaf, neck and finger blasts in both the trials. It reflected in high grain yield during rabi 2019 and 2020. Followed by Tricyclazole + Mancozeb 62%WP spray (T4) treatment recorded the lesser incidences of finger millet blasts. Antibiotics and bio-control agents are showed the least recovery of blast incidences under field conditions (Table 2&4). The Tricyclazole, sole and also as constituent new molecule fungicides are effectively controlled the finger millet blast pathogen under field conditions. Both the treatments are on-bar with each other. In this condition the B:C ratio analyzed through partial budgeting method. All the new molecule of fungicides recorded considerable yield increase than bio-control agent and antibiotics (1:1.40 to 1:1.50). Tricyclazole alone (T3) recorded as 1:2.00 and combined with Mancozeb (T4) recorded as 1:1.98 during rabi, 2019 and 2020 (Table 3&5 Chart 1). New generation chemical, Tricyclazole can offered effective management against rice blast pathogen (Singh et al., 2000). Similar report of Raj and Pannu (2017) also showed the managing rice blast pathogen by Tricyclazole and Propiconazole under field condition and Mohiddin et al. (2021) reported that the Tricyclazole was most effective against rice blast and recorded a leaf blast incidence of only 8.41%. Neelkanth et al. (2017) found that tricyclazole, was found drastically controlling the pathogen with the lowest PDI (Per cent Disease Index), in addition significant increase in the yield was observed in tricyclazole sprayed plots as compared to other fungicides. In rice ecosystem, fungicides proved very effective control against Pyricularia oryzae (Dutta et al., 2012; Prajapati et al., 2004; Sood and Kapoor, 1997). For pearl millet blast, Carbendazim and Tricyclazole showed effective control under in vivo conditions (Joshi and Gohel 2015; Lukose et al., 2007). On the other hand, rice blast pathogen isolates showed differential sensitivity to Tricyclazole and Carbendazim (Yuan and Yang, 2003; Mohammad et al., 2011).