Formulation and Development of Nanoparticles of Quassia Amara for Treatment of Diabetes

Author: Kanchan B. Bendkule, Ashish Y. Pawar, Khanderao R. Jadhav, Jahnavi D. Borse and Madhura S. Chothave

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Abstract

The green synthesis of nanoparticles uses plant components as reducing agents to create silver nanoparticles, including carbohydrates, lipids, enzymes, flavonoids, terpenoids, polyphenols, and alkaloids. The most common cases reported in all over world are those related to diabetes mellitus. Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily due to type 1diabetes mellitus and gestational diabetes. Green synthesis of nanoparticles provides nanomaterial benefits ranging from antidiabetic properties to natural reducing properties and stabilizing properties. Due to its insolubility in water, the diabetic drug Quassia amara L. has a poor bioavailability. The purpose of this study is to increase solubility of drug by formulating novel Quassia amara L. nanoparticles using the solvent evaporation method; thus, enhancing bioavailability. Drug and excipient compatibility study was carried out by FTIR. The prepared formulations were evaluated for visual examination, percentage yield, drug entrapment efficiency, drug content, FTIR, particle size, polydispersity index, zeta potential, SEM, In-vitro drug release, kinetic assessment study and In vitro antidiabetic study. The optimized formulation shows particle size 148.5nm. The zeta potential was found to be -28mV while Entrapment efficiency was found to be 92.5%. Maximum drug release can be confirmed through in-vitro testing. i.e., 82.99 % in 8hr. comparison of alpha-amylase inhibition of the acarbose and Quassia amara L. nanoparticles shows anti-diabetic activity.

Keywords

Nanoparticles, Quassia amara L., Diabetes, Poly-dispersity index, Zeta potential, Entrapment efficiency

Conclusion

The developed formulation exhibits good organoleptic qualities, according to all the observations and results. When both drug and excipient were characterised, no undetectable peaks were found in the FT-IR study. The entrapment efficiency was found to be optimised formulation is 92.5%. the drug content of prepared nanoparticles ranges between 71.5% to 53.7%. Th particle size of then a no particles is 148.5 nm. The zeta potential was found to be -28 mV, which indicates good formulation stability. One of the main benefits of nanoparticles over conventional drug administration is this. The in-vitro drug release study confirmed that Quassia amara L. was released for a long time. The kinetic assessment of in-vitro release of Quassia amara L. nanoparticles was also performed. Finally, we derived from this comprehensive analysis that site-specific activity can be successfully achieved using Quassia amara L. nanoparticle formulation.

References

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How to cite this article

Kanchan B. Bendkule, Ashish Y. Pawar, Khanderao R. Jadhav, Jahnavi D. Borse and Madhura S. Chothave (2023). Formulation and Development of Nanoparticles of Quassia Amara for Treatment of Diabetes. Biological Forum – An International Journal, 15(5): 1616-1626.