Formulation, Evaluation, Development, Characterization, and In Vitro Evaluation of Sulfasalazine hydrogel for the treatment of Oral Lichen Planus

Author: Shoaib A. Shaikh, Sharav A. Desai, Ravi S. Khandare and Bhagwat H. Garje

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Abstract

Sulfasalazine topical hydrogel is a type of s medicine applied directly to the skin to reduce inflammation, irritation, and pain. Topical Sulfatase hydrogel is useful against the use of corticosteroids. Sulfasalazine, an anti-inflammatory drug, has limited solubility in both aqueous and organic solvents. Achieving its effective dispersion within the hydrogel matrix poses a significant challenge. To overcome this hydrogel was prepared by using modifying polymers, Carbopol 934 P. Physicochemical properties of the drug were evaluated by ultraviolet, Fourier transforms infrared spectroscopy (FTIR), and solubility study. Hydrogel appearance clarity, pH, viscosity, extrudability, rangeability, drug content, surface pH, in vitro drug release, Ex vivo permeability, stability study histopathology study, and release of kinetics model. The FTIR studies showed no evidence of interactions between drugs, polymers, and excipients. Formulation F4 achieves an in vitro drug release of 81.67% ± 0.28 at 2 h and fine evaluation results. We successfully developed hydrogel formulations of Sulfasalazine and describe an effective result for the treatment of OLP for resistance to corticosteroid therapy.

Keywords

Sulfasalazine, Hydrogel, Ulcer, Fibroblast, In-Vitro ulcer

Conclusion

Thus stable, effective gels containing Sulfasalazine along with ingredients for the management of mouth ulcers can be developed. In conclusion, this study strongly suggests the simplicity and practicality of the new gel. The use of this novel gel might provide shielding from the olp conditions, as reflected in promoting the speed of healing, enhancing epithelialization, and minimizing the use of corticosteroids.

References

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How to cite this article

Shoaib A. Shaikh, Sharav A. Desai, Ravi S. Khandare and Bhagwat H. Garje (2023). Formulation, evaluation, development, characterization, and In Vitro Evaluation of Sulfasalazine hydrogel for the treatment of Oral Lichen Planus. Biological Forum – An International Journal, 15(5): 481-491.