Hemophilia A (HA) is a disease of inheritance, stated as a factor VIII deficiency. Despite low incidence, HA usually involves repeated bleeding episodes leading to joint damage and negative impact on patients’ HR-QoL. This analysis aimed to assess the HR-QoL in children with HA and influential factors on their HR-QoL. A study of cross-section was done to examine HR-QoL in all children of HA, hospitalized at Children’s Hospital. Face-to-face interview with patients and their parents has been conducted using Peds-QL 4.0 SF-15 questionnaire from January to June, 2018. Data were analyzed in SPSS using relevant statistical test with 95% confidence level. 126 patients with the mean age of 10.8 ± 4.0 years have been chosen for the study and classified into 3 groups: 5-7 years (27.8%), 8-12 years (32.5%) and 13-18 years (39.7%). 50.8% of patients had severe disease status, 65.9% had bleeds in the joints with average disease duration of 9.67 ± 4.33 years and average treatment period of 4.

Hemophilia A, life quality, children, adolescents, Peds-QL, Vietnam.

The result of this study indicated that the HR-QoL of children with HA was impaired moderately. Furthermore, education level, age group, disease duration were associated with Peds-QL scores. In addition, site of bleeding was the factor that was relevant to the total scores reported by patients. Therefore, this needs more concerns of care and future studies are necessary in order to improve HR-QoL of HA children.

Thuy, N.T.T., Huyen, M.L., Thu, T.A. (2019). Health-Related Quality of Life in Children with Hemophilia A: A Single Center Study from Vietnam. Biological Forum - An International Journal, 11(2): 97-102.