Histomorphological Alterations in Goat Testicular Tissues by Cyfluthrin and Its Restoration by Vitamin E

Author: A.K. Sharma and Ambika Gandhi

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Abstract

The aim of this study was to reveal the impact of cyfluthrin on goat testicular tissue and its restoration by vitamin E. The culture of testicular tissue was done for 4 and 8 hours. Cyfluthrin was given to testicular tissues in two concentrations, i.e., 100 μg/ml and 200 μg/ml, while vitamin E (0.1 M/ml) was given to testicular tissues having the above-mentioned concentrations of cyfluthrin to study its mitigating effects. Cyfluthrin has been found to cause severe damage to testicular cells, as there was a decrease in the number of spermatozoa and spermatids, vacuolization of the lumen of the germ cells, and decreased sperm lumen in cyfluthrin-treated groups. The addition of vitamin E reduced the number of apoptotic cells, vacuolization, and desquamation of germ cells in the lumen and pyknotic cells. In comparison to the treatment group, the sperm population increased and the shape of the seminiferous tubules improved. Vitamin E, an antioxidant, prevented cyfluthrin-induced testicular damage in vitro and restored fertility in goat testes exposed to the drug. The findings of this study will be extremely helpful in assessing the potential health risks of cyfluthrin in domestic animals and will also be used as an in vitro model for research on the effects of xenobiotics on mammals and will have implications in determining the harmful effects that can cause reproductive damage. The outcomes of this study will support the use of vitamin E in the physiological treatment of negative effects brought on by cyfluthrin exposure in ruminants.

Keywords

Spermatozoa, cyfluthrin, Testis, spermatids, Vitamin E

Conclusion

Cyfluthrin has a significant impact on mammals' reproductive system, impairing spermatogenesis, according to the findings of this study. The testis' normal structure significantly improved after Vitamin E administration. To lessen the harmful effects of pesticides and insecticides, vitamin E supplementation is suggested. Cyfluthrin's negative effects on domestic animals and their amelioration by antioxidants like Vitamin E will be assessed using the findings of this study, which will also be used to develop strategies and approaches to manage its negative effects.

References

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How to cite this article

A.K. Sharma and Ambika Gandhi (2023). Histomorphological Alterations in Goat Testicular Tissues by Cyfluthrin and Its Restoration by Vitamin E. Biological Forum – An International Journal, 15(5): 1595-1597.