Hyperthermia Augments Chemotherapy on Supraglottic Carcinoma: A Case Report

Author: Damodarakumaran, Gugloth Vikas Babu, Subramanyan Sevvel and Mustaq Ahamed

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Abstract

Supraglottic carcinoma is the dominant laryngeal tumor common in India due to chronic alcohol abuse and smoking. Patients often present with non-specific throat pain, dysphagia, and neck lymphadenopathy as the primary disease features of supraglottic carcinoma. In this study, we report a case of a 61-year-old male with a complaint of pain over the right neck with swelling, an open wound with white discharge, and was diagnosed with supraglottis malignancy stage IV with N3 metastasis. The patient was put under the first chemotherapy treatment cycle with paclitaxel, carboplatin, and local hyperthermia (HPT) on the supraglottis. After HPT treatment, the tumor responded and was controlled well, the cancer wound was shrunken, and the pain was reduced significantly. Neoadjuvant chemotherapy and regional HPT have additive antitumor and antimetastatic effects promoting patient recovery. HPT approach has significant merits, especially for treating superficial and deep metastatic sites.

Keywords

Anticancer, carcinoma, chemotherapy, hyperthermia, supraglottic neoplasm

Conclusion

The present study investigated the most promising treatment modalities for supraglottic carcinoma using a combination of hyperthermia and chemotherapy. The cancers in the supraglottic region are usually superficial compared to other forms of deep organ malignancies, and it is very appropriate to use hyperthermia along with chemotherapy to control cancer. The synergistic effect of hyperthermia and chemotherapy also augments the rate of wound healing, pain reduction, and swelling, suggesting that chemotherapy and regional HPT have additive antitumor and antimetastatic effects promoting patient recovery. HPT approach has significant merits, especially for treating superficial as well as deep metastatic sites. However, it should be noted that hyperthermia is not suitable for all types of cancer, and several factors, such as tumor location, stage, and patient comorbidities, can influence its effectiveness. Therefore, its use in cancer treatment should be evaluated case-by-case.

References

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How to cite this article

Damodarakumaran, Gugloth Vikas Babu, Subramanyan Sevvel and Mustaq Ahamed (2023). Hyperthermia Augments Chemotherapy on Supraglottic carcinoma: A Case Report. Biological Forum – An International Journal, 15(5): 1482-1485.