Immunomodulatory Potential of Simarouba glauca DC., Leaf and Stem Bark extract, in vivo

Author: N. Navya, K. Sandesh, Rajeshwara N. Achur and N.B. Thippeswamy

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Abstract

Natural products are celebrated to primarily modulate the immune system in nonspecific ways. A number of plant-based principles have been acknowledged and isolated with potential immunomodulation activity which validate their use in traditional folklore medicine and can form the base of further specified research. Here, we investigated the immunomodulatory activity of Simarouba glauca DC., leaves and stem bark extract at the doses of 100, 200 and 300 mg/kg body weight in mice followed by the immunostimulatory activity as cyclophosphamide suppressed immune system, phagocytic activity using carbon clear test, T-cell population test and anti-inflammatory activity were carried out. In the carbon clearance test, SGL and SGB extracts exhibited a significantly high phagocytic index indicating the stimulation of reticuloendothelial system. A significant decrease in mean difference, in the foot paw thickness in carrageenan-induced paw edema activity, indicates its anti-inflammatory activity. Both SGL and SGB aqueous extract treated groups at 200 and 300 mg/kg doses showed a significant increase in T-cell population due to raise in T-cell rosette formation. These results confirm the immunomodulatory activity of SGL and SGB aqueous extract, which is a known immunomodulator in indigenous medicine.

Keywords

Immunomodulators, Simarouba glauca DC., T-cell rosette assay, anti-inflammatory

Conclusion

Overall, the present study affirms that the aqueous extract of Simarouba glauca DC., leaves and stem bark is an effective immunomodulatory agent. The effectiveness of extract‑treated animals in overcoming the side effects of CP-induced immunosuppression provides evidence for the balancing and adaptogenic effectiveness by exhibiting a similar mechanism as that of levamisole in restoring immunosuppression. These results also support the fact that water-soluble components derived from these extracts have an important effect on the immune system and can effectively modulate immunological interactions. Thus, based on this preliminary study, it can be concluded that the SGL and SGB aqueous extracts hold the promise for its use as a novel immunostimulating agent. However, further detailed studies are needed to validate these findings.

References

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How to cite this article

N. Navya, K. Sandesh, Rajeshwara N. Achur and N.B. Thippeswamy (2023). Immunomodulatory Potential of Simarouba glauca DC., Leaf and Stem Bark extract, in vivo. Biological Forum – An International Journal, 15(4): 350-357.