Impact of Emblica officinalis Fruit Extract on ATPases System under AD-induced conditions in Albino Rat

Author: Kuna Yellamma and Mude Thulasi

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Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by memory loss, cognitive impairment and personality disorders. There is presently no treatment for this illness despite substantial investigation. However, recent studies have shown therapeutic qualities in Emblica officinalis, natural extract. The aim of this study was to evaluate the efficacy of Emblica officinalis fruit methanolic extract on ATPase activity in the Cerebral Cortex and Hippocampus regions of AD-induced rat brain. Male albino rats which are, 3 months old disease free and experimental animals weighing between 150±25 grams were utilized in the study. They were divided into three groups as described in the materials and methods section. Rats from different groups were sacrificed by cervical dislocation. Cerebral Cortex and Hippocampus regions were isolated and used for estimation of 3 constituents of the ATPase system at selected time intervals. The results demonstrated that the ATPase levels in both brain regions of the AD-induced rats were inhibited while they were brought back to near control levels upon continuous oral administration of Emblica officinalis extract on 60th day of treatment thus demonstrating that EoFM extract had reversal effects on AD induced changes in ATPae system.

Keywords

Emblica officinalis, Male Albino rat, D-Galactose, ATPases, Cerebral Cortex and Hippocampus

Conclusion

According to the findings of this study, it was evident that EoFME administration to AD-Induced rats normalized the activities of Na+/K+, Mg2+ and Ca2+ -ATPases indicating that EoFM has the potential to maintain ion gradients across biological membranes. They were founded on the concept that adding EoFME to the rat diet boosts membrane-bound transport ATPase activity, which is linked to its anti-oxidative effects. Furthermore, Emblica officinalis fruit extract may produce a variety of beneficial secondary metabolites that are engaged in a number of brain biochemical processes and so protect neurons by stabilizing the structural and functional integrity of the biological membrane.

References

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How to cite this article

Kuna Yellamma and Mude Thulasi (2023). Impact of Emblica officinalis Fruit Extract on ATPases System under AD-induced conditions in Albino Rat. Biological Forum – An International Journal, 15(5): 1734-1740.