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In vitro Anticancerous and Antimicrobial Activities of Curcuma amada Mediated Silver Nanoparticles

Author: Thiagu G., Raja P., Suganthi P., Thilip C., Musfir Mehaboob V., Aslam A. and Shajahan A.

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Abstract

Silver nanoparticles are extensively studied due to their exceptional physicochemical and biological features. Phytocompound based silver nanoparticles are considered as a unique and potentially useful alternative process for chemically synthesized nanoparticle. Curcuma amada rhizome mediated Ag NPs anticancerous and antimicrobial activities were analyzed. In vitro anticancerous studies against human breast cancer (MDA MB-231) cell lines and antimicrobial studies against gram positive (Staph. aureus, Bacillus subtilis) and negative (Pseudomonas aeruginosa, Escherichia coli) were studied. Increased concentrations of the silver nanoparticles showed increased cytotoxicity in the tumor cell lines (MDA MB-231) with IC50 observed as 163.5µg/ml. Among the tested bacterial species with different concentrations (10, 20, 40, 60, 80, 100, 200, 300, 400 and 500µg/ml) of green Ag NPs, P. aeruginosa showed high growth inhibition (14.7±0.8mm.) at 30µg/ml. Our study concluded that green synthesized Ag NPs by C. amada rhizome extract showed an efficient anticancerous and antimicrobial properties.

Keywords

Silver Nanoparticles, C. amada, Anticancerous, Inhibition Zone, Cytotoxicity.

Conclusion

Green chemistry of Ag NPs using C. amada rhizome is a concise, safe and one-step procedure. Phytocompounds present in the synthesized nanoparticles elevated the reduction reaction on the tumor cells and pathogenic microorganisms. Altered membrane integrity resulted in the cytotoxicity of the tumor cells and the microbes.

References

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How to cite this article

Thiagu G., Raja P., Suganthi P., Thilip C., Musfir Mehaboob V., Aslam A. and Shajahan A. (2023). In vitro Anticancerous and Antimicrobial Activities of Curcuma amada Mediated Silver Nanoparticles. Biological Forum – An International Journal, 15(4): 504-507.