Influence of Organic pH Modifiers on Molecular Interactions and Sustained Release of Methyl Eugenol in Angstrom Void Polymer (AVP) Gel Matrix Formulation

Author: S. Kannan, Lokesh Makam and S.P. Venkatesh Prasad

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Abstract

Methyl eugenol (ME) is widely used as fruit fly attractant in infested agricultural fields. But the biggest challenge is to develop sustained release formulation for slow and sustained release of ME, which can be effectively used for prolonged period when deployed in open fields. In the present study evaluating sustained release activity of ME using Angstrom Void Polymer (AVP) gel matrix formulation, the experimental results depicted that the pH of AVP gel matrix influences ME molecules to exhibit variable weak ionic attraction forces with acrylic acid units of the polymer gel as well as the surface adsorption, influx, and efflux movement of ME from the 3D molecular sieves of zeolites 4A. This behaviour of ME significantly influences the sustained release property of ME loaded AVP gel matrix. In the present study, ME charged Carbopol 940 gel formulation when coupled with ME charged Zeolites 4A, and the resultant matrix modulated with organic pH modifiers, the experimental results showed a significant increase in sustained release activity of the matrix. The experimental results exhibited that ME release rate was influenced by changes in pH of the matrix, which alters the amphoteric nature of the Zeolites 4A and influences the changes in attractive forces between ME and Zeolites 4A also ME interaction with Carbopol 940 gel in the matrix. The present experimental results clearly demonstrate the relationship between pH and sustained release property of the AVP gel matrix for ME. The results clearly demonstrated, when pH changes from more acidic to less acidic it improves the sustained release property of the matrix and at less acidic 6.5 pH sustained release effect of ME was optimal and exhibited a sustained release of ME with an average release of 33.33±0.06mgs per day effectively for 56 days, with a loading dose 2gms of ME into the zeolite 4A dispersed Carbopol 940 gel; AVP gel matrix formulation (Indian patent applied; Patent Application Number: 201741016813).

Keywords

Methyl Eugenol (ME), Carbopol 940 gel, Zeolites, AVP gel matrix

Conclusion

Present experimental results clearly demonstrate the direct relationship between pH of the Carbopol 940 aqueous gel and its impact on Zeolites 4A for the molecular intrusion, influx, and efflux of ME molecules from the 3D molecular sieves as well as surface adsorption property for ME. Thus, by modulating the pH of the AVP gel matrix system, in and out movement of ME from the molecular sieves of Zeolites 4A, ionic interaction, and surface adsorption of ME with AVP gel matrix can be modulated. These interactive properties of the ME depend on the chemical nature of active ingredient and pH of the matrix. In the present experimental study, sustained release activity of the AVP gel matrix was achieved for 56 days at pH 6.5 for the pheromone ME. Thus, the developed AVP gel matrix formulation can be deployed in open agricultural fields for effectively attracting fruit flies.

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How to cite this article

S. Kannan, Lokesh Makam and S.P. Venkatesh Prasad (2023). Influence of Organic pH Modifiers on Molecular Interactions and Sustained Release of Methyl Eugenol in Angstrom Void Polymer (AVP) Gel Matrix Formulation. Biological Forum – An International Journal, 15(4): 767-770.