INTRODUCTION Milk fever or Parturient paresis or Hypocalcemiais a metabolic disease most commonly occurring in adult females before or after parturition, commonly occur within 48 hours of parurition. There is a rapid decline in plasma calcium level from eucalcemic level for the formation of colostrum and also low calcium absorption from the intestines due to reduced feed intake and improper calcium-phosphorus ration in diet with vitamin D deficiency (Deniz, 2007). High-yielding Cow and Buffalos are commonly affected. Milk fever may also result in the downer cow syndrome, grass tetany, ketosis, udder edema, abomasal displacement, metritis, and poor fertility (Peter et al., 2007).Its clinical symptoms include sever muscle weakness, Sternal or Lateral recumbency with predominant Sub-normal temperature. Milk fever causes serious Economical loss to farmers, as it might lead to dystocia and even uterine prolapse (Rajadurai et al., 2021).With this background, the present case study deals with the Successful medical management of Milk fever in a Crossbred Jersey cow. CASE HISTORY AND CLINICAL FINDINGS An Adult Crossbred jersey cow of age about three years was diagnosed with Milk fever which was maintained at SR dairy farms in Thuraiyur, Tiruchirappalli district of Tamilnadu. The animal had a history of calved twenty hours before and was unable to stand observed by the farm attenders. Upon clinical examination, the animal was at Lateral Recumbency, per rectal temperature was about 101.2 F, with cold extremities and Bloated appearance. On physical examination all other vital parameters were normal. Pupillary light reflex was also absent. Based on the animal's history and clinical symptoms, it was diagnosed as Milk fever and the necessary treatments were started immediately without further delay. TREATMENT The cow was treated with calcium borogluconate @ 1 mg per 45kg bodyweight intravenously for hypocalcemic condition. The signs of Milk Fever disappeared within thirty minutes after the administration of calcium borogluconate hence the prognosis was good. To prevent the reoccurrence of hypocalcemic condition the attenders were advised to give oral calcium supplements @ 100mL/ day for seven days. DISCUSSION Milk fever is one of the commonest disease conditions occurring in cattle and buffalos during parturition. The probability is high in adult animals ageing 5-10 years. Based on the time of occurrence, Parturient paresis can classified into prepartum, postpartum and subclinical hypocalcemia. It’s mainly due tothe low serum calcium levelas a result of calcium loss in colostrum formation, reduced intestinal absorption, insufficient mobilization of calcium from the storage pool during the parturition. 6 percent of dairy cattle in the US are affected by hypocalcemia which is characterized by extremely low blood calcium concentration (Oetzel and Goff 1998). Metabolic diseases are common in high-yielding dairy cows during the periparturient period (Hibbs, 1950; Chiwome et al., 2017). Calcium homeostasis is very difficult to maintain in these animals during this period because of physiological and pathological factors. This can lead to the development of milk fever, which predisposes the animal to a variety of other disorders (Fikadu et al., 2016). Farmers must be educated about proper ration formulations and the importance of mineral supplements to their dairy cows hence poor feeding and dietary deficiency are the primary predisposing factor for milk fever in cows (Rajadurai et al., 2021). As per Goff et al. (1989), intravenous administration of parathyroid hormone prevents parturient paretic hypocalcemia in dairy cows. Six and three days before calving the animal may be administered with 25-hydroxycholecalciferol and its synthetic analog 1α-hydroxycholecalciferolto prevent the milk fever (Murray et al., 2008). In the present case, the cow was affected with a stage two milk fever, which was identified by sternal recumbency and curving of the neck to the side. Stage one and two milk fever can be treated effectively by intravenous administration of calcium. However, stage 3 milk fever is difficult to treat especially when muscle paralysis has been ensured (Hutjens and Aalseth 2005).