Natural Cancer Immunity in Naked Mole Rat: A Review

Author: Manju, Kanika Pathak and Sawan Kumar

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Abstract

The present understanding of naked mole rat which is cancer resistant is examined in this research paper. The review will examine the crucial issue of cancer resistance in naked mole rat and concentrate on the reasons why people are more susceptible to cancer than this animal. Studying their genes that are resistant to cancer in order to treat human cancer sickness involves the proliferation, tumour growth and development of cancer in humans. The review specifically discusses cancer in the first section before moving on to why naked mole rat are resistant to the disease and outlining the mechanisms involved. Modern techniques detect cancer in early stages which decreases the death rate and increases the recovery of cancer patient. The review will then examine the cancer treatment from the perspective of the gene present in naked mole rat that fight cancer utilised in pharmacological treatment

Keywords

Contact inhibition, Sand puppy (naked mole rat), Subterranean mole rat, Fibroblastic cells

Conclusion

Many cancer-resistant species share some of the same evolvable processes, whilst other evolvable mechanisms are unique to specific clades of cancer-resistant species. HMM-HA, which limits cell division and slows the formation of premalignant cells, has evolved in sand puppy. Independently, the demand for more potent anticancer defences has emerged. In many evolutionary groupings which explains why tumor suppressor mechanism are so diverse. Simply said, mice do not have additional anticancer defences that people do not. The possibility for accelerating the creation of antitumor medicines is significantly greater with regard to animals that are naturally cancer-resistant. Humans may lack the anticancer characteristics that these species have developed and if these adaptations were added to human cells, cancer resistance may grow. As humans do not live a subterranean lifestyle, they did not evolve HMM-HA, hence it may be advantageous to activate analogous systems in humans. The body naturally contains HA, which is well tolerated. Finding methods significantly increase HMM-HA levels in human beings could therefore be used to cure cancer or prevent it in people who are at risk of developing it. There are numerous naturally cancer-resistant animals outside of the conventional laboratory inventions which means nature has a lot to give in the quest for novel tumor suppressor strategies. In addition to the elephants mentioned here, the subterranean mole rat, the microbat, the sand puppies and the cows were also discovered to be very resistant to breast cancer. For example, it is possible to produce mice that overexpress the hyaluronan synthase gene from naked mole rats. The development of pharmaceutical therapies to imitate the cancer-resistant animal adaptations for use on humans is possible if these mice models go on to demonstrate enhanced tumour resistance. Anticancer adaptations with a question mark indicate those for which the precise molecular mechanisms are not known

References

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How to cite this article

Manju, Kanika Pathak and Sawan Kumar (2024). Natural Cancer Immunity in Naked Mole Rat: A Review. Biological Forum – An International Journal, 16(10): 172-175