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Optimization and Evaluation of Topical Gel from Euphorbia hirta L extract Towards Skin Infections

Author: Abilesh Ramesh, Divya Kennedy, Vijayalakshmi Subramanian and Vaidevi Sethuraman

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Abstract

Skin disease is the most common disease caused to humans, according to World Health Organization (WHO) around 900 million experience skin diseases. Skin diseases are caused due to allergies, irritants, genetic makeup, certain diseases, and immune system problems. Microbes like Candida albicans, Propionibacterium, Staphylococcus, and Escherichia coli are important reasons for cause of skin disease. To overcome this issue, there is a need of medication that cures skin infections like acne, cellulitis, cutaneous candidiasis, boils and furuncles in one solution. In this research article, we developed a novel plant-based topical gel from Euphorbia hirta L. The extract of E. hirta and silver nanoparticles loaded in the gel showed good activity against E. coli, Propionibacterium, Staphylococcus, and Candida albicans. Thereby, the formulated gel would be promising skin care product that cures acne, cellulitis, cutaneous candidiasis, boils and furuncles.

Keywords

Skin disease, E. hirta L, topical gel, optimization, antibacterial, antifungal

Conclusion

The formulated gel showed good properties of topical-like stability and the optimization describes the effectiveness of the formulated topical gel. The ethanolic extract of Euphorbia hirta L showed good antimicrobial activity, also the formulated gel incorporated E. hirta extract and AgNPs showed better activity against bacteria and fungi like E.coli, S. aureus, P. acne, C. albicans, respectively. These bacteria and fungi causes acne, cellulitis, cutaneous candidiasis, boils and furuncles. Antimicrobial activity showed that the formulated gel would cure the disease caused by those microbes. Therefore, we conclude that the resulting topical gel would be effective in curing skin infections.

References

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How to cite this article

Abilesh Ramesh, Divya Kennedy, Vijayalakshmi Subramanian and Vaidevi Sethuraman (2023). Optimization and Evaluation of Topical Gel from Euphorbia hirta L extract Towards Skin Infections. Biological Forum – An International Journal, 15(5): 1115-1123.