Pharmacological Activities of Pyrimidine Derivatives: An Overview

Author: Prakash Pansare, Harichandra Parbat and Anna Pratima Nikalje

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Abstract

The present review article highlights the therapeutic potentials of pyrimidine derivatives, which are valuable for medical applications in the new generation. Heterocyclic compounds, including pyrimidine, offer a wide range of structural diversity and have demonstrated significant usefulness as therapeutic agents. Pyrimidine is compound that is similar to pyridine aromatic heterocyclic and is one of the three diazines. Extensive research has shown that heterocyclic pyrimidine derivatives play crucial roles in the pathophysiology of various diseases. The pyrimidine nucleus, a fundamental component of DNA, has been found to exhibit diverse biological activities. These include antimicrobial, anticancer, anti-inflammatory, antidiabetic, and analgesic activities. This review article aims to provide an overview of the reported work on the therapeutic potentials of pyrimidine derivatives, highlighting their significance in medical applications for the new generation.

Keywords

Pyrimidine, pyrimidine derivatives, pyrimidine nucleus, Pharmaceutical, Antimicrobial, Antiviral

Conclusion

The work offers fresh insights into the applications of pyrimidine derivatives in medicine and pharmacology. This overview demonstrates the wide range of illnesses for which pyrimidine derivatives have been investigated. Pyrimidines and their derivatives have been linked to a variety of pharmacological effects, such as those that are antimicrobial, antiviral, anticancer, antifungal, anti-inflammatory, antimalarial, antidepressant, anticonvulsant, antithyroid, anti-alzheimer, anti-angiogenic, anti-hepatitis, anti-diabetic, and analgesic.

References

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How to cite this article

Prakash Pansare, Harichandra Parbat and Anna Pratima Nikalje (2023). Pharmacological Activities of Pyrimidine Derivatives: An Overview. Biological Forum – An International Journal, 15(5): 1767-1775.