Potential Bioactive Compounds to Treat Alzheimer’s Onset: A review

Author: Mohan Kumar B.S., Suresh Kumar C. and Narasimha Murthy V.N.

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Abstract

Neurological disorders affecting aging individuals are characterized by neurodegeneration, posing a severe health risk. With the aging population increasing globally, the incidence of such diseases is escalating, creating a growing public health concern. Alzheimer's disease (AD) is the most prevalent cause of age-related dementia, and currently, no effective therapies exist to prevent, delay, or reverse its course. However, various studies have indicated that lifestyle changes, including diet, could postpone or prevent the onset of AD. Food is increasingly recognized as a crucial component in maintaining good health, preventing oxidative stress and chronic inflammation, and avoiding chronic degenerative diseases. Preprobiotics, nutraceuticals containing bioactive compounds with antioxidant and anti-inflammatory properties, and anti-protein aggregation molecules are essential in preventing and treating cognitive impairment and AD. This study focuses on natural plant-derived compounds and their derivatives, demonstrating neuroprotective activity and providing promise for treating and preventing AD.

Keywords

Alzheimer's disease, galantamine, huperzines, berberine, aporphine, polyphenols, flavonoids, curcumin, terpenoids, resveratrol

Conclusion

Natural compounds have gained significant attention as potential therapeutic agents for the treatment of Alzheimer's disease due to their diverse pharmacological activities and relatively fewer side effects. The various natural compounds discussed in the article, including curcumin, omega-3 fatty acids, flavonoids, terpenoids, and resveratrol, have shown promising results in preclinical studies and clinical trials. However, further research is necessary to determine their effectiveness, safety, and optimal dosage for the treatment of Alzheimer's disease. Overall, natural compounds provide a promising avenue for the development of novel therapeutics for Alzheimer's disease and other neurodegenerative disorders.

References

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How to cite this article

Mohan Kumar B.S., Suresh Kumar C. and Narasimha Murthy V.N. (2023). Potential Bioactive Compounds to Treat Alzheimer’s Onset: A review. Biological Forum – An International Journal, 15(5): 906-911.