Siddha system of medicines treats diseases using herbs, metals and minerals. One such gem of siddha formulation is Kabasura kudineer which efficient in treating respiratory disorders. Due to the lack of systemic data the current study conducted to evaluate the safety profile of the choornam in rats by OECD subacute toxicity. A total of 30 rats divided into 15 male and 15 female were grouped in 3 at three dose levels Kabasura kudineer 200mg, 400mg, 800mg. Body weight evaluated every week. Food consumption and water intake were noted every day. After 28 days the animals were sacrificed, blood and organ were collected haematological analysis, Biochemical parameters performed using the blood. The organs used for histopathological studies. The subacute toxicity proved that no toxicity or symptoms were seen in the rats and the study should be proceeded with non-rodent species

Kabasura kudineer, Subacute toxicity, Sprague Dawley rats, Haematology, Biochemistry

In the subacute toxicity experiments, the Kabasura Kudineer did not result in any toxic effects or other symptoms. This suggests that Kabasura Kudineer is not particularly harmful. It is important to perform additional research on the toxicology of this product in non-rodent species or on humans. The Kabasura Kudineer did not cause any signs of toxicity or any other symptoms in the subacute toxicity studies. That indicates that Kabasura Kudineer is relatively non-toxic. Further study regarding the toxicology of this preparation should be conducted in non-rodent species or in humans

Parvatharajakumaran V.S., Deepika Rani S., Premkumar B., Leela Priyanka G.C., Sruthy Jacob, Rabiyamma S. and Syed Hussain Peeran S. (2023). Preclinical Toxicological Evaluation of Siddha Formulation, Kabasura Kudineer by Sub-Acute Toxicity Studies. Biological Forum – An International Journal, 15(3a): 23-27