Irreversible Histopathological Modifications Induced by Iron Oxide Nanoparticles in the Fish, Oreochromis mossambicus (Peters, 1852)

Author: P.V. Vidya and K.C. Chitra

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Abstract

The aim of present study is to investigate if the histopathological alterations induced by iron oxide nanoparticles (Fe3O4NPs) in the fish Oreochromis mossambicus is reversible after the treatment withdrawal. Sublethal concentration (15 mg/L) of Fe3O4NPs was exposed to fish for short-term (96 h) and long-term (60 days) durations along with control group. Histopathological modifications in gill, liver and brain tissue were examined after the exposure periods. Gill tissue showed blebbing of gill epithelium, mucous deposition, vacuolization, hyperplasia of gill arches, aneurysm and loss of secondary lamella after short- term and long-term exposure of nanoparticles. Exposure to Fe3O4NPs in liver tissue resulted in segmentation of hepatocytes, vacuolization, spindle shaped nucleus, necrosis and aggregation of melanomacrophages, where the severity of lesions increased in time-dependent manner. Lesions of brain tissue included degeneration and severe loss of granular cells after 96 h followed

Keywords

Fe3O4NPs, Gill, Liver, Brain, Histopathology, Oreochromis mossambicus.

Conclusion

To brief, Fe3O4NPs at sublethal concentration caused pronounced tissue damage to the fish, which is irreversible. Thus proper measures should be taken to avoid the release of nanoparticles into the aquatic ecosystems, or else eventually leads to the change in physiological and behavioural modifications and finally results in the decline of fish population.

References

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How to cite this article

Vidya, P.V. and Chitra, K.C. (2019). Irreversible Histopathological Modifications Induced by Iron Oxide Nanoparticles in the Fish, Oreochromis mossambicus (Peters, 1852). Biological Forum – An International Journal, 11(1): 01-06.