Evaluation of Anticonvulsant Activity of Ethanolic & Aqueous Extract of Hemidesmus indicus L. Stem & Leaves and Lantana camara L. Stem & Flowers on Experimental Animals

Author: Javed Khan Pathan, Girendra Gautam and Arun Kumar Gupta

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Abstract

The aim of present study was to investigate anticonvulsant activity of ethanolic & aqueous extract of stem & leaves of Hemidesmus indicus and ethanolic & aqueous extract of stem & flowers of Lantana camara in wistar rats. Anticonvulsant activity was studied against maximal electroshock seizure (MES) induced convulsions in rats. The extracts suppressed hind limb tonic extensions (HLTE) induced by MES induced seizures. Study includes ethanolic & aqueous extract of stem & leaves of Hemidesmus indicus (200 and 400 mg/kg, p.o.) and ethanolic & aqueous extract of stem & flowers of Lantana camara (200 and 400 mg/kg, p.o.). The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted. The effects were compared to those of Phenobarbitone (30 mg/kg, i.p). The preliminary phytochemical analysis identified alkaloids, flavonoids, saponins and large amounts of cardiac glycosides, triterpenoids, phenolic compounds and tannins in extracts. The extracts of H.

Keywords

Hemidesmus indicus, Lantana camara, anti-convulsant activity, maximal electro shock, MES, GABA, hind limb tonic extension seizure (HLTE), H. indicus, L. camara.

Conclusion

The results obtained from the study suggested that stem & leaves extracts of H. indicus and stem & flowers extracts of L. camara have excellent anti-convulsant property which are possibly mediated partly via facilitation of GABA transmission and the results verify its traditional use in epilepsy. It has been minutely observed that aqueous extracts of both plant parts exhibit better anticonvulsant property than that of ethanolic extracts of both plants. Secondly it has been found that ethanolic extract & aqueous extract of H.indicus stem have 87.05% and 89.01% respectively and ethanolic extract & aqueous extract of same H. indicus leaves have 82.15% and 88.23% respectively. Thirdly observed that ethanolic extract & aqueous extract of L. camara stem have 83.00% and 87.00% respectively and ethanolic extract & aqueous extract of same L. camara flowers have 78.00% and 84.31% respectively as compare to the standard drug. In totality finding clearly shows that aqueous extracts are better

References

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How to cite this article

Javed Khan Pathan, Girendra Gautam and Arun Kumar Gupta (2019). Evaluation of Anticonvulsant Activity of Ethanolic & Aqueous Extract of Hemidesmus Indicus L. Stem & Leaves and Lantana Camara L. Stem & Flowers on Experimental Animals. Biological Forum –