Impact of Serum Interleukin 6 (IL-6) Level of Patients with Acute & Chronic Hepatitis B Virus

Author: Ali A. Dawood

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Abstract

Hepatitis B infection is a global health problem. Hepatitis B virus infects liver and causes inflammation reaching to hepatocellular carcinoma. The human interleukin 6 (IL-6) is a multifunctional cytokine that interfere in the regulation, maturation and differentiation of immune response. The aim of this study is to demonstrate the interleukin 6 (IL-6) and correlates with ALT and AST levels in patients serum with hepatitis B virus. We evaluate 58 patients presumably with HBV in acute and chronic cases whom have HBsAg positive. AST and ALT chemical serum levels were detected using kits of an automated chemical analyzer. IL-6 serum level was detected using ELISA technique. Correlation between parameters were done using One-ANOVA and Analyse-it statistical software. IL-6 serum level is raised with acute hepatitis B patients more than of chronic hepatitis B with high concentration absorption. The AST and ALT levels were elevated with AHB group more than CHB group. The correlation between I

Keywords

AHB, CHB, IL-6, HBsAg, AST.

Conclusion

In conclusion, our data indicated that serum levels of IL-6 elevated with the increase of AST levels in patients with acute hepatitis B. The serum levels of IL-6, AST and ALT varied in different courses of acute and chronic hepatitis B virus infections. We surmised that IL-6 level might indicate liver injury of patients with acute hepatitis B infections. Moreover, negative correlation coefficient was emerged between chemical parameters and hepatitis cases according with age serial groups.

References

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How to cite this article

Dawood, Ali A. (2019). Impact of serum Interleukin 6 (IL-6) level of patients with acute & chronic Hepatitis B virus. Biological Forum – An International Journal, 11(1): 248-254.