Investigation of antimicrobial activity of Nano sized particles of oxindoles and compression their activity with tetracycline and gentamic in drugs

Author: Somayeh Makarem*, Leila Pishkar** and Taheri Saba***

Download PDF

Abstract

We reported clean one-pot technique for the preparation of nano particles of oxindole derivatives by using isatins and indoles in the presence of constant current as catalyzer. The product was characterized after purification using IR, 1H NMR, 13C NMR, MS, and SEM. the synthesized compounds have been screened for their antibacterial activities Some of nano particles of oxindole were showed antimicrobial activities against some gram positive and negative bacteria’s.

Keywords

Oxindoles, Constant Current, Antimicrobial, Nanoparticles

Conclusion

at the present time, growing resistance of pathogens against anti-bacterial compounds used is a common and vital problem, which shows obviously that research on new com-pounds against these pathogens is needed. We synthesized 3 substituted Nano sized particles of oxindoles and screened their antimicrobial activities, nanoparticles of 3a-3c display antimicrobial activities against some gram positive and negative bacteria’s and compound 3a shows antimicrobial activities better than Tetracycline and Gentamicin.

References

-

How to cite this article

Somayeh Makarem*, Leila Pishkar** and Taheri Saba (2016). Investigation of antimicrobial activity of Nano sized particles of oxindoles and compression their activity with tetracycline and gentamic in drugs , Biological Forum – An International Journal 8