Evaluation the Inhibitory Effect of Atorvastatin and the Olibanum Extract to Reduce Bleomycin-induced Pulmonary Fibrosis

Author: Salehe Asgary* and Iraj Javadi**

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Abstract

Bleomycin is an effective antibiotic with anti-tumor activity that has a minimum toxic effect on hematopoietic tissues and the immune system and can be widely used with the other chemotherapeutic agents. Lung injury is the most devastating side-effect of the anti-cancer drug Bleomycin which often progresses to pulmonary fibrosis. The objective of the present study is to evaluate antioxidant and anti-inflammatory effects of Atorvastatin and the extract of Olibanum on Bleomycin-induced pulmonary fibrosis. Male Wistar rats were randomly divided into four groups. The positive control group received Bleomycin Sulfate (1 U/100 gBW) intra-tracheal. In the negative control group, normal saline and propylene glycol (PG) and in the combination group, 10 mg/kgAtorvastatin and simultaneously 120 mg/kg hydro-alcoholic extract of Olibanum were injected intraperitoneally a week before Bleomycin administration and treatment was continued until 14 days afterwards. The levels of Malondialdehyde (MDA) an

Keywords

Bleomycin, pulmonary fibrosis, Atorvastatin, Olibanum

Conclusion

The surveys show that combination of two mentioned materials can reduce the progress of pulmonary fibrosis. Bleomycin injection causes an increase in the lung weight of mice compared to the normal lung. Asgary and Javadi 246 This increased weight can be due to edema and fluid accumulation in the lung tissue which an appropriate space is provided because of the damage and destruction of alveoli and also duo to collagen accumulation which is the characteristic of Bleomycin-induced pulmonary toxicity (Selman et al., 2001). The lung weight ratio to the total body weight of the animal showed the most amount in Bleomycin group which is probably because of edema and pulmonary infiltration. On the other hand, weight loss due to animal's anorexia and its destructive effect has caused a rise in this index. In the pulmonary fibrosis disease, Malond

References

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How to cite this article

Salehe Asgary* and Iraj Javadi (2016). Evaluation the Inhibitory Effect of Atorvastatin and the Olibanum Extract to Reduce Bleomycin-induced Pulmonary Fibrosis , Biological Forum – An International Journal 8(1): 241-247.