The Effect of Oral Administration of Bisphenol A on Tissue and Liver Enzymes, Serum Lipids and Blood Glucose in Rats

Author: Mahnaz Taherianfard*, Sara Abdolmaleki**, Zahra Alimoradi***, Hamidreza Afsoun**** and Mohammad Alimoradi*****

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Abstract

Bisphenol A (BPA) is a synthetic compound of carbon with chemical formula (CH3)2C (C6H4OH)2. In this study 20 adult male rats were selected and divided into 4 groups of 5including group I (Control), group II (Shame) and groups III and IV(receiving BPA at doses of 5 and 50 μg/kg/day respectively). BPA was given to rats by gavage for 15 days and blood samples were collected. Serum lipids (Triglyceride, Total Cholesterol, HDL and LDL), Serum liver enzymes (AST, ALT and ALP) and serum glucose values were measured. According to the data, using BPA at 2 doses caused a significant reduction (P<0.05) in liver enzymes level and a significant increase in LDL level, but had no effect on lipids and blood sugar. BPA at the low dose caused a significant increase in Triglyceride. Therefore within these doses and during the research (2 weeks), BPA does not cause fatty liver.

Keywords

Bisphenol A, Liver Enzymes, Lipids, Blood Sugar

Conclusion

The results suggest that administration at high and low doses of BPA have been significantly decreased the liver enzymes and it has not cause any significant change in serum total cholesterol, serum HDL and serum glucose levels, but has led to the increase of LDL cholesterol level.

References

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How to cite this article

Mahnaz Taherianfard, Sara Abdolmaleki, Zahra Alimoradi, Hamidreza Afsoun and Mohammad Alimoradi (2016). The Effect of Oral Administration of Bisphenol A on Tissue and Liver Enzymes, Serum Lipids and Blood Glucose in Rats , Biological Forum – An Internat