Use of Piperine as a Natural Bioenhancer in Formulation Development and Evaluation of Mouth Dissolving Film of Ziprasidone

Author: Prashant L. Pingale, Sahebrao S. Boraste, Dattatraya M. Shinkar, Anjali P. Pingale and Sunil V. Amrutkar

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Abstract

The most recent technology for creating oral disintegrating dose forms is oral film. Low drug loading and few options for flavour masking are these dosage forms' principal drawbacks. The oral film is made up of different-sized and shaped ingestible water-soluble polymers. When a medicine is taken, it is released for either stomach absorption or oral mucosal absorption. Ziprasidone HCI, piperine, bio-enhancers, and other standard chemicals such polymers, plasticizers, sweeteners, saliva-stimulating agents, and flavours have been combined to create a mouth-dissolving film. The moment the film is applied to the patient's tongue and mucous tissue; saliva starts to spit on it. The film quickly absorbs water and sticks to the application place before immediately dissolving. The optimized formulation (F3) demonstrated good mechanical qualities, folding durability, and mouthfeel in addition to immediate drug release. The major goal of this study was to create a mouth-freshening film that dissolves in the mouth. The film (F3) samples that were tested had a rapid drug release profile, with the maximal release occurring in 3 minutes and a quicker start to the medication's action. The stability investigations took place for between one and three months. No significant changes were made to the drug release, in-vitro disintegration, thickness, or tensile strength.

Keywords

Absorption, Bioenhancer, Drug release, Mouth dissolving film, Ziprasidone

Conclusion

The main goal of this research was to create a mouth-dissolving film using the bioenhancer piperine, Ziprasidone HCl, as well as basic components such polymers, plasticizers, sweeteners, saliva-stimulating agents, and flavours. Solvent casting was used to create the films. Piperine accelerates drug breakdown, increasing CDR by up to 99%. The HPMC E5 cps was unable to give the film thickness. HPMC E15 had good adaptability. Propylene glycol, a plasticizer, was unable to give the film flexibility and folding durability. Good folding durability, tensile strength, and % elongation was achieved using PEG 400. The improved formulation (ZF3) demonstrated good mechanical qualities, folding durability, and mouth feel in addition to immediate drug release. In comparison to the commercial formulation, the ZF3 demonstrated a 31-second reduction in disintegration time and 99% drug release in just three minutes. Therefore, it was believed that the use of piperine as a natural bioenhancer, which is favourable and offers maximal drug release compared to standard dosage form, had produced quick drug release for an instant start to activity.

References

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How to cite this article

Prashant L. Pingale, Sahebrao S. Boraste, Dattatraya M. Shinkar, Anjali P. Pingale and Sunil V. Amrutkar (2023). Use of Piperine as a Natural Bioenhancer in Formulation Development and Evaluation of Mouth Dissolving Film of Ziprasidone. Biological Forum – An International Journal, 15(1): 156-162.