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Significant Impact of Ginger Extract on Oxidative stress Markers and Lipid Peroxidation in Diabetic Male Albino Rats

Author: D. Veera Nagendra Kumar, C. Narasimha Rao, U. Srineetha, C. Nageswara Reddy, P. Sachidevi and S. Prakash Rao

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Abstract

The role of oxidative stress has been reported in various diabetes complications. This study's objective was to determine whether ginger supplementation at a dose of 200 mg/kg body weight was beneficial at protecting diabetic rats produced by the drug streptozotocin (STZ). Adult male albino rats weighing 180–200 g were given STZ (40 mg/kg body weight) intraperitoneally to develop diabetes. Glibenclamide (600 g/kg body weight) was the recommended medication. Blood glucose, uric acid, MDA concentration, and Xanthine oxidase (XOD) activity were all greater in diabetic rats' brain homogenates. They found that the brain tissue had lower amounts of ascorbic acid, glutathione, and GST activity. We found that diabetic rats given oral supplementation of ginger extracts and glibenclamide had lower MDA, uric acid content, XOD activity and higher levels of GST, ascorbic acid, and GSH in the brain as well as higher body weight. Since ancient times, ginger or Zingiber officinale has been used as a herbal remedy to cure a variety of diseases. Recent research has shown ginger's promise as a diabetic mellitus therapy. These finding suggest that ginger extract therapy has a protective effect against the progression of diabetes through reducing oxidative stress and brain oxidative stress.

Keywords

Ginger, STZ, Diabetes, Blood glucose, XOD, GST, Brain

Conclusion

The results of this investigation suggested that ginger could improve the health and metabolic efficiency of diabetic rats. Because of this, ginger could be used to make natural diabetes treatments. Considering that ginger has antioxidant and anti-diabetic characteristics, it may be clinically useful in the control of human diabetes.

References

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How to cite this article

D. Veera Nagendra Kumar, C. Narasimha Ra, U. Srineeth, C. Nageswara Redd, P. Sachidevi and S. Prakash Rao (2023). Significant Impact of Ginger Extract on Oxidative stress Markers and Lipid Peroxidation in Diabetic Male Albino Rats. Biological Forum – An International Journal, 15(1): 412-418.