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Anti-hyperbilirubinemic Potential of Aqueous Extract of Mimosa pudica Roots in Wistar Rats

Author: Rupali A. Patil, Pradhnya M. Ghate, Shubhangi H. Pawar, Manisha A. Tayde and Suvarna A. Katti

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Abstract

Paracetamol and Phenylhydrazine (PHZ)-induced hyperbilirubinemia in rat is due to elevated bilirubin content causing damage to the liver. It is associated with hemolysis of RBC’s which causes an over production of Bilirubin. Effect of aqueous extract of Mimosa pudica L. roots (AEMP) was investigated using paracetamol and PHZ-induced hyperbilirubinemia in Wistar rats. In both models, the common parameters estimated were serum Bilirubin, Hemoglobin (Hb), serum levels of liver biomarker enzymes viz., aspartate transaminase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), various in vivo biochemical parameters like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and extent of lipid peroxidation (LPO) in the liver. Serum bilirubin and blood hemoglobin levels were measured on day 1, 5 and 10. AST, ALT and ALP levels measured on day 5 and 10. Paracetamol and PHZ exhibited significant increase in the level of bilirubin and LPO while levels of other parameters significantly decreased on 10th day. AEMP exhibited significant decrease in the levels of bilirubin and LPO and increase in the levels of other parameters on 10th day. Present study indicates that aqueous extract of Mimosa pudica root shows potential antihyperbilirubinemic activity associated with antioxidant activity in both the models indicating usefulness in various liver disorders.

Keywords

Bilirubin, Hyperbilirubinemia, Jaundice, Mimosa pudica, Paracetamol, Phenylhydrazine

Conclusion

From the above study it can be concluded that aqueous extract of roots of Mimosa pudica possesses an anti-hyperbilirubinemic activity which may be attributed to the antioxidant activity and alkaloids indicating its usefulness in treatment of liver disorders.

References

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How to cite this article

Rupali A. Patil, Pradhnya M. Ghate, Shubhangi H. Pawar, Manisha A. Tayde and Suvarna A. Katti (2023). Anti-hyperbilirubinemic Potential of Aqueous Extract of Mimosa pudica Roots in Wistar Rats. Biological Forum – An International Journal, 15(1): 576-581.