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Synthesis and Anticonvulsant Activity of 3,5-Bis[(5’-Substituted Phenyl) 1,3,4-Oxadiazole] 1,4-Dihydropyridine

Author: Honde Bharat S., Kadm Sai V., Shelke Pratiksha S., Chimankar Ayushi D., Kale Rutuja B. and Kanhe Nandini K.

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Abstract

The reveals that the 1.4-Dihydro Pyridine and 1’,3’,4’-oxadiazole are pharmacologically more active units. The reaction of substituted aromatic or benzene substituted aldehydes with ethyl acetoacetate ammonia formation of diethyl 2, 6-dimethyl-4-(substituted Phenyl)1,4-dihydropyridine 3,5-dicarboxylate (I), which on reaction with hydrazine hydrate formation of 2, 6-dimethyl-4-(substituted Phenyl)1,4-dihydropyridine 3,5-dicarbohydrazide (II), added with substituted benzoic acid in presence of phosphorous oxychloride final formation of 2, 6-dimethyl-4-(substituted Phenyl)1,4-dihydropyridine 3,5-[bis-(5’-substituted 1’,3’,4’-oxadiazole)] 1,4-dihydropyridine (3a-3l). Purity was checked by TLC and chemical structure of synthesized derivatives were elucidated by their IR, Proton NMR, MS analysis data. According to dose 30 mg/ml concentration as compared to Phenytoin 5mg/ml standard drug. The synthesized derivatives were screened for anticonvulsant activity.

Keywords

1,4-dihydropyridine, Oxadiazole, IR, NMR, MS, Anticonvlsant

Conclusion

After 30 mins derivatives 3b, 3i, 3k showed better activity. After 60 mins. Derivatives 3a, 3b, 3f showed better activity. After 90 mins. Derivatives 3f, 3j, 3k showed better activity. After 120 mins. Derivatives 3f, 3g, 3k showed better activity. We’re as the remaining derivatives exhibited moderate activity. From the anticonvulsant data of the synthesized derivatives, we can conclude that the derivatives 3a, 3f and 3k have exhibited excellent anticonvulsant activity in MES model and hold promise as anticonvulsant agents after further development.

References

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How to cite this article

Honde Bharat S., Kadm Sai V., Shelke Pratiksha S., Chimankar Ayushi D., Kale Rutuja B. and Kanhe Nandini K. (2023). Synthesis and Anticonvulsant Activity of 3,5-Bis[(5’-Substituted Phenyl) 1,3,4-Oxadiazole] 1,4-Dihydropyridine. Biological Forum – An International Journal, 15(2): 42-45.