Formulation and Evaluation of Orodispersible Bilayer Tablet containing Fenoprofen Calcium

Author: Sobhit S. Rajput and Deepak Marothia

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Abstract

Conventional compressed tablets are associated with certain limitations associated to their delayed plasma drug concentration and difficulty in swallowing (Dysphagia). Orodispersible tablets, seem to circumvent the above-mentioned limitation and can facilitate oral administration in pediatric and geriatric patients. Current work aimed to achieve rapid therapeutic effects; typically suggested for geriatric and paediatric patients because to enhanced compliance, bioavailability, simplicity of administration, and palatability. Fenoprofen Calcium orodispersible tablets were made using the direct compression method and a coprocessed superdisintegrant (Crospovidone + Ac-Di-Sol). The absorbance, MP, and FTIR spectra of the bulk drug were evaluated in order to characterise it. There was uniformity and repeatability in the measurements for tablet thickness, weight variation, percent drug, wetting time, in vitro disintegration time, and in vitro dissolution tests after compression. Within 25 minutes, all formulations (ODT1-ODT9) demonstrated a nearly 100% drug release rate. The fastest Fenoprofen Calcium release was recorded in the case of ODT9: in 10 min, 58.554%, and in 25 min, 98.72%. The current study concluded that increasing the amount of coprocessed superdisintegrants decreased tablet disintegration time and increased cumulative drug release, all of which resulted in increased absorption.

Keywords

Direct Compression, Fenoprofen Calcium, Coprocessed superdisintegrant, Factorial design

Conclusion

The idea of creating fenoprofen calcium rapid disintegration and dissolution characteristics of orodispersible bilayer tablets with coprocessed super disintegrants are appropriate and useful. Studying the absorbance, melting point, and FTIR spectroscopy allowed researchers to characterise fenoprofen calcium. ODT1, ODT2, and ODT3 formulations were prepared with 8 mg of Ac-di-sol and 8 mg, 16 mg, and 24 mg of Crospovidone, resulting in a % drug release in the order ODT1

References

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How to cite this article

Sobhit S. Rajput and Deepak Marothia (2023). Formulation and Evaluation of Orodispersible Bilayer Tablet containing Fenoprofen Calcium. Biological Forum – An International Journal, 15(2): 358-364.