Formulation and Development of Oral Dental Films of Doxycycline Loaded Chitosan Films for efficient Treatment of Periodontitis

Author: Jaydeep Dusane and Ashok Bhosale

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Abstract

The present study demonstrates the development of intrapocket dental films of Doxycycline for efficient treatment of periodontitis. The films were developed by solvent casting method using chitosan, TPP, and PEG 400 as polymer, crosslinking agent, and plasticizer respectively. The developed films were characterised by physicochemical properties including drug release, tensile strength, and bactericidal activity against E. coli and Staphylococcus aureus. One of the major challenges was achieving uniform drug distribution in the chitosan matrix. Doxycycline has poor solubility in water and acidic pH, which are the conditions required for chitosan gelation. To get uniform drug distribution proper mixing of the drug was carried out in polymeric dispersion. All physical parameters of the films were found to be acceptable for dental application. It was observed that the drug release occurred in a sustained manner. The optimised film formulation was found to be stable over 2 months at accelerated conditions. This newly developed film could be used as a potential alternative drug delivery system for peridontitis conditions.

Keywords

Doxycycline, chitosan, TPP, PEG 400, bactericidal

Conclusion

The aforementioned results justify the use of Doxycycline in films developed with chitosan, TPP, and PEG 400 as polymer, crosslinking agent, and plasticizer respectively. The films' physicochemical characteristics were deemed to be acceptable. It was discovered that the drug release occurred in a sustained manner. The DOX-loaded films demonstrated good bactericidal efficacy against E. coli and Staphylococcus aureus. The drug did not interact chemically with the excipients while being stored at accelerated stability conditions. This newly developed film could be used for future medication delivery applications in peridontitis conditions.

References

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How to cite this article

Jaydeep Dusane and Ashok Bhosale (2023). Formulation and Development of Oral Dental Films of Doxycycline Loaded Chitosan Films for efficient Treatment of Periodontitis. Biological Forum – An International Journal, 15(3): 06-15.