Comparative Evaluation of different Marketed Brands of Levetiracetam Tablet

Author: Prakash S. Sukhramani, Mahesh K. Senghani, Sharav Desai, Nitin G. Sutar and Vipul P. Patel

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Abstract

Epilepsy is one of the utmost prevalent neurological conditions; its primary treatment is the administration of antiepileptic drugs (AEDs). An antiepileptic medication with excellent pharmacologic properties is levetiracetam (LEV) which shows initiative in improving seizure control. For the treatment of focal onset, myoclonic, and primary generalized seizures in both adults and children, levetiracetam has been recommended. It shows a significant affinity for a synaptic vesicle protein (SV2A). The study was assessed to find out the parameters of different brands of LEVETIRACETAM tablets I.P. in Mandvi region, Kutch (Gujarat) to match them typically with the standard parameters of I.P. specifications. The tablets available in the market of several brands were taken for investigation and tablets were evaluated for different quality control tests like weight variation, hardness, friability, disintegration time, and dissolution rate. The recorded weight variation was<10%, and hardness results were less than 4-10 kg-ft. and the friability results were also not more than 1 %. As per the in-vitro dissolution of each brand, the results observed more than 70% release.

Keywords

Levetiracetam, Anti-epilepsy, physicochemical Parameters, Immediate release, Tablet

Conclusion

The pharmaceutical sector relies on a variety of factors to maintain quality, including employee qualifications, the quality of active pharmaceutical components, validation of the production process, location, etc. All the brands of tablets utilized in the study's weight variation, hardness, friability, disintegration time, and dissolving test were within IP-specified limits. Acceptable hardness, friability, disintegration time, and dissolving profiles were displayed by most of the brands. Nonetheless, when compared to the other brands, B4 and B5 exhibited good dissolving profiles. This work can be a usefulsuggestion in the case of seeking compatibilities of the sample formulations along with the standardsmentioned in the official Pharmacopoeia. This study supports the necessity for ongoing, thorough monitoring of Levetiracetam tablets that are sold in the nation to assure their quality and that their maintenance is directly related to public health.

References

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How to cite this article

Prakash S. Sukhramani, Mahesh K. Senghani, Sharav Desai, Nitin G. Sutar and Vipul P. Patel (2023). Comparative Evaluation of different Marketed Brands of Levetiracetam Tablet. Biological Forum – An International Journal, 15(2): 520-527.