Formulation and Evaluation of Hylocereus Undatus for Treatment of Psoriasis

Author: Jayshri B. Sanap, A.V. Chandewar, Mayuri G. Zore, Vaishnavi V. Chore, Aachal V. Ingle and Nitin K. Kochar

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Abstract

The pitaya, from the cactus family, sometimes called dragon fruit or dragon fruit, has aroused the curiosity of connoisseurs of the subject for its unique flavor, shape, and color. Also documented the functions of H. polyrhizus seeds, including their antioxidant capacity, and the use of various parts of H. undatus to promote wound healing in diabetic rats. This study aimed to determine the relationship between ethanol and Helicobacter pylori. Efficacy of pericarp undatus and a reformulated gel containing botanical components of H. undatus pericarp extract on ultraviolet-induced psoriasis in rats. Herbal remedies are widely claimed to be effective in treating various skin conditions. Unfortunately, no research supports their use in psoriasis. The acute dermal and oral toxicity of ethanolic extracts of plant bark in gels and suspensions has been studied. Acute dermal toxicity results at 1% w/w and oral toxicity data at 1000 mg/kg indicate that the gel and suspension are safe. Wistar rats developed psoriasis by exposing 10% of their body to ultraviolet light. 2.5% and 5% gels were used to test antipsoriatic activity. The severity index, histological examination, and biochemical analysis were studied. Our results indicate that the test formulation (gel) of plant bark extract has antipsoriatic activity.

Keywords

Dragon fruit, psoriasis, phytochemical screen, UV-C induced photodermatitis, Perry mouse tail model

Conclusion

On the basis of the results obtained in our study, it is observed that the seed contains high amounts of phytochemicals which have various activities like anti-cancerous activities, anti-microbial activities, antioxidant activities, etc. Various approaches are available for topical drug delivery system which fulfills pharmacotherapeutic aspects as well as patient compliance. Herbal formulations have growing demand in the world market as natural products are more acceptable in the belief that they are safer than synthetic one. However, for treatment of topical gel shows better results as compare to cream and ointment. The gel were prepared and evaluated for various physicochemical and performance characteristics and compared with marketed gel. Hylocereus undatus shows anti-psoriatic activity by reducing the thickness of epidermal layer, presence of stratum granulosum layer in ultraviolet-C induced psoriasis whereas orthokeratosis in Perry’s mice tail model compared with control group. In Ultraviolet- C induced psoriasis model Hylocereus undatus shows significant reduction of epidermal layer thickness & presence of Stratum Granulosum. In Perry’s scientific mice tail model Hylocereus undatus shows significant orthokeratosis % which is absent in mice.

References

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How to cite this article

Jayshri B. Sanap, A.V. Chandewar, Mayuri G. Zore, Vaishnavi V. Chore, Aachal V. Ingle and Nitin K. Kochar (2023). Formulation and Evaluation of Hylocereus undatus for the Treatment of Psoriasis. Biological Forum – An International Journal, 15(2): 724-731.