Review on Nanoparticle Loaded Oral Film an Innovative Approach for Poorly Water-Soluble Drug Delivery

Author: Dipak P. Kardile, Pravin B. Awate, Vishwas C. Bhagat, Adinath C. Bhusari, Nilesh A. Narote, Rajkumar V. Shete, Tushar B. Shinde and Mayur M. Karne

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Abstract

In this review Nanoparticle loaded oral film have been employed in this method of oral drug delivery to maximize therapeutic benefits while reducing toxic and unfavorable medication effects because enhances the pharmacokinetic and pharmacodynamics characteristics of (BCS) II and IV APIs capable of achieving targeted delivery and easy to provide oral drug delivery of API for high patient compliance for pediatric, geriatric, bedridden patients. More than 50% of APIs are having difficulty in the preparation of oral dosage form due to their poor oral bioavailability and aqueous solubility, primarily APIs in the Biopharmaceutical Classification System (BCS) II and IV. Therefore, API incorporated in Nanoparticles which have high drug carrier capacity, high stability and increase permeability as well as solubility in body fluid. The Nano encapsulated API loading in oral film is challenging occurs in formulation it overcome by selecting better film forming agent. Oral films are effective than oral fast-disintegrating tablets (OFDTs) to overcome the chocking problem for dysphagia and it provide, rapid onset of action, safety and efficacy, excellent dissolution profile.

Keywords

Nanoparticle, Nanoparticle Preparation, oral film, Method of Preparation, Composition of oral film

Conclusion

The benefits of including NPs loaded oral film have been examined in this paper. This data demonstrates that it is feasible to make films containing NPs with suitable physical-mechanical properties in a single formulation process. Encapsulating active components in Nano materials has been used to increase the stability and permeability of bio macromolecules and reduce their toxicity. NPs can thus be easily converted to oral films and are amenable to being prepared to alter the pharmacokinetic profile of active pharmaceutical ingredients. In order to transform unstable physiologically active molecules into promising deliverable pharmaceuticals, difficulties associated with poorly soluble or insoluble lipophilic drug in both organic and aqueous phases must be properly addressed. Additionally, advancements are required to turn the Nano-oral film technology hypothesis into a workable, real-world strategy as the next generation of drug delivery systems. The suggested method may improve patient compliance by increasing solubility and permeability in oral mucosa. This analysis leads us to the conclusion that Nano particle loaded oral film is promising drug delivery system for poorly water soluble and low permeability drug by solving problems associated with it by increasing bioavailability.

References

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How to cite this article

Dipak P. Kardile, Pravin B. Awate, Vishwas C. Bhagat, Adinath C. Bhusari, Nilesh A. Narote, Rajkumar V. Shete, Tushar B. Shinde and Mayur M. Karne (2023). Review on Nanoparticle Loaded Oral Film an Innovative Approach for Poorly Water-Soluble Drug Delivery. Biological Forum – An International Journal, 15(3): 138-146.