Molecular Docking Analysis of Bergenin and 11-o-gallyl Bergenin from Mallotus philippensis against Anti-oxidant Proteins

Author: Y. Jhansi Laskshmi, R. Durga, G. Sashikanth Reddy, P.S. Harika and Y. Suneetha

Download PDF

Abstract

One of the critically endangered medicinally significant plants used in traditional systems of medicine is Mallotus philippensis, which has the potential for cultivation. It is a significant Ayurvedic medicinal shrub, and the entire plant is loaded with secondary metabolites. The plant's various parts are used to treat conditions like cancer, diabetes, diarrhea, urinogenital infection, bronchitis, abdominal disease, jaundice, malaria, antifungals, tape-worms, and eye disease. Additionally, it possesses a variety of pharmacological properties, including antioxidant, antimicrobial, anti-filarial, anti-leukemic, anti-tumor, anti-HIV, and hepatoprotective properties. We aimed in this study to perform molecular docking to two compounds from Mallotus philippensis against two anti-oxidant proteins SOD and GPX. The results showed that 11-o-galloylbergenin has a high docking score and binding affinity to both protein receptors as compared to bergenin. The demonstrated biological potentials declared that compounds could be the better natural antioxidant candidate. The resulting data is extremely valuable for phytotherapeutics continued development as a cancer treatment.

Keywords

Mallotus philippensis, Molecular docking, SOD, GPX. 11-o-galloylbergenin, bergenin

Conclusion

In the present study, two biologically active compounds from M. philippensis were Bergen in and 11-O-galloylbergenin. Therefore, it is concluded that the isolated compounds' proven medicinal properties could be used as building blocks for the creation of advanced natural products and may be crucial for the development of new drugs.

References

-

How to cite this article

Y. Jhansi Laskshmi, R. Durga, G. Sashikanth Reddy, P.S. Harika and Y. Suneetha (2023). Molecular Docking Analysis of Bergenin and 11-o-gallyl Bergenin from Mallotus philippensis Against Anti-oxidant Proteins. Biological Forum – An International Journal, 15(3): 592-596.