Antidiabetic, Pancreas Protective and Antioxidant Potential of Ethanol Extract of Botryocladia leptopoda (J. agardh) Kylin on Streptozotocin-Induced Diabetic Rats

Author: Suthan P. and Selvamaleeswaran P.

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Abstract

In this study, ethanol extract of Botryocladia leptopoda (J. Agardh) Kylin was subjected to analysis of its antidiabetic activity in STZ provoked diabetes animals. This study was undertaken to investigate the effect of Botryocladia leptopoda (Et-Bl) ethanol extract on glucose level, biochemical parameters, and carbohydrate metabolizing enzymes, in vivo antioxidants, and histological study of the pancreas in streptozotocin-induced diabetic rats. Different doses of Et-Bl (100, 200, and 300 mg/kg BW) were administered orally for 60 days. The effects were compared with glibenclamide. Treatment with Et-Bl and glibenclamide for 60 days resulted in a significant alteration in glucose level, biochemical parameters and carbohydrate metabolizing enzymes, in vivo antioxidants, and histological study of the pancreas. The effect at a dose of 300 mg/kg of Et-Bl was more pronounced than that of 100 and 200 mg/kg BW and brought all the parameters to near normal. Thus, the present findings suggest that Et-Bl may be considered an effective therapeutic agent for treating diabetes mellitus.

Keywords

Antioxidants, Antidiabetic, Ethnomedicine, Botryocladia leptopoda, Streptozotocin

Conclusion

Our study determines effect of Et-Bl in diabetic rats. Et-Bl reduces hyperglycemia by increasing external glucose consumption and modulating glycolysis and gluconeogenesis. Et-Bl was as effective as glibenclamide. Et-Bl leaves were taken orally to manage diabetes and prevent complications.

References

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How to cite this article

Suthan P. and Selvamaleeswaran P. (2023). Antidiabetic, Pancreas Protective and Antioxidant Potential of Ethanol Extract of Botryocladia leptopoda (J. agardh) Kylin on Streptozotocin-Induced Diabetic Rats. Biological Forum – An International Journal, 15(6): 129-137.