Biological Activities of some Sterically Congested Organoantimony (v)-Carboxylates, -(Halo) Carboxylates and -Pseudohalides

Author: Mayank Jaiswal, Manish Arya, Prem Raj and Santosh Kumar Singh

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Abstract

Since the initial discovery of applications of Antimony complexes in the clinical treatment of many kinds of disease, efficiency of Antimony complexes in inhibiting the expansion of various types of Antifungals, Antibacterial and Antitumor disease. A series of Sterically Congested Organoantimony(v)-Carboxylates, -(Halo) Carboxylates and –Pueudohalides [ (α-C6H11)3Sb(NCS)2, (cyclo-C6H11)3Sb(NCS)2, (α-C6H11)3Sb(N3)2, (cyclo-C6H11)3Sb(N3)2, (cyclo-C6H11)3Sb(2-Pyrazine Carbox.)2] complexes were evaluated for their activity against Antifungal, Antibacterial and Antitumor disease. One of the main obstacles in my work is that complex should sometimes not be oriented correctly. In this research work the derivatives shown promising results against Antifungal, Antibacterial and Antitumor disease and the derivatives oriented correctly with the metal which shown optimum biological activity.

Keywords

Organoantimony (v), Antifungal, Antibacterial, Antitumor

Conclusion

In conclusion, organoantimony(v) compounds are highly versatile and attractive reagents for the advancement of synthetic organic chemistry. Organoantimony (v) compounds are easily synthesised from low-toxicity antimony salt. These compounds are mostly trivalent and pentavalent, with antimony in the +3 and +5 oxidation states. Organoantimony compounds have a wide range of applications in organic chemistry, as well as organometallic, medicinal and polymer chemistry. Organoantimony compounds have received less attention than other lighter pnictogens. Experimental studies on the antifungal, antibacterial, and antitumor activities of organoantimony (v) compounds revealed that they are better biocides than hydrocarbon-based ligands, which may be due to the presence of Florine atoms, which causes electronical and chemical changes in the molecule, it is reasonable to believe that the future of organoantimony chemistry should lead to interesting and valuable discovery.

References

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How to cite this article

Mayank Jaiswal, Manish Arya, Prem Raj and Santosh Kumar Singh (2023). Biological Activities of some Sterically Congested Organoantimony (v)-Carboxylates, -(Halo) Carboxylates and -Pseudohalides. Biological Forum – An International Journal, 15(5a): 74-86.