Therapeutic Role of Phytonutrients in Chronic Respiratory Diseases in the Indian Population

Author: Pallab Ray

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Abstract

The respiratory tract’s chronic inflammation is an extremely worrisome public health concern in India because it may develop into CRDs, some of which pose a greater threat than others. COP), & asthma are examples of chronic respiratory conditions. The dilemma of representative chemotherapy to treat respiratory distress necessitates discovering the medications that successfully combat the modern complexities of the target sickness. Chronic pulmonary illnesses are characterized by several intricate regulatory mechanisms, necessitating chemotherapeutics with composite inhibitory action. Cost-effective & natural product-based molecules are more likely to meet the challenges that respiratory-distress treatment poses by avoiding the laborious archetypes of drug designing & development, showing a strong case for a probable substitute of poly-pharmacology, & guaranteeing disease-relapse prevention. The cell signalling pathways & components of natural product moieties are summarised in this study to show how successful they are as a therapy for respiratory ailments affecting the Indian population. The study of the therapeutic role of phytonutrients in chronic respiratory diseases in the Indian population faces significant challenges because of the heterogeneity of patient profiles and disease severity. Moreover, the diverse dietary habits and lifestyle factors across different regions of India may influence the response to phytonutrient-based interventions, necessitating careful consideration in study design and interpretation. Despite these challenges, research on the medicinal applications of phytonutrients, including their anti-inflammatory, antioxidant, and immunomodulatory capabilities, has made notable advances in our knowledge of their mechanisms of action. Clinical research has produced encouraging results, including increased lung function, decreased airway inflammation, and improved quality of life for those with chronic obstructive pulmonary disease (COPD) and asthma. The creation of tailored and individualized therapies for various chronic respiratory illnesses is made possible by the identification of phytonutrients with positive therapeutic profiles. Additionally, including phytonutrients as adjunctive therapy in standard medical procedures has the potential to improve patient outcomes and reduce the need for traditional drugs, which could result in more cost-effective healthcare administration. Realizing the full potential of phytonutrients as beneficial complements to managing chronic respiratory disorders requires collaboration between academics and healthcare providers.

Keywords

Chronic respiratory diseases, Phytonutrients, Indian population, different age groups, cell signalling

Conclusion

Chronic respiratory illnesses are primarily brought about by bronchial & pulmonary inflammation resulting from a heightened innate response, which causes an increase in pro-inflammatory metabolites. Inflammatory cells’ recruitment into the bronchial & alveolar mucosa is proofd through the inhalation of toxicants. Even after a lengthy stimuli cascade, the persistence of non-specific macrophages & adaptive T-lymphocytes inadvertently stimulates the memory cells of adaptive immunity, a phenomenon that is sustained by dendritic cells that promote the remodelling of lung tissue. Additionally, oxidative stress & disruption of the balance of protease/antiprotease reduce corticosteroids’ efficacy to decrease airway inflammation.

References

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How to cite this article

Pallab Ray (2023). Therapeutic Role of Phytonutrients in Chronic Respiratory Diseases in the Indian Population. Biological Forum – An International Journal, 15(5a): 126-134.