Herbal Interventions for Drug-Induced Nephrotoxicity: An Overview of Pedalium murex Linn and Hygrophilla auriculata

Author: Riyazunnisa D., Kanala Somasekhar Reddy and Suggala V. Satyanarayana

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Abstract

Drug-induced nephrotoxicity, a common adverse effect of numerous medications, poses a significant challenge to healthcare providers and patients. Traditional herbal interventions have gained attention as potential therapeutic strategies for mitigating drug-induced nephrotoxicity due to their natural properties and minimal side effects. However, despite their promise, incorporating herbal remedies into conventional treatments presents challenges in terms of standardization, dosage determination, and potential herb-drug interactions. This review article provides an overview of two herbal remedies, Pedalium murex Linn and Hygrophilla auriculata, which have shown promising nephroprotective effects. Pedalium murex Linn, commonly known as 'Gokhru', has been traditionally used in Ayurvedic medicine for its diuretic, anti-inflammatory, and antioxidant properties. Experimental studies have demonstrated its ability to attenuate drug-induced renal damage, protect against oxidative stress, and reduce inflammation markers in animal models. Hygrophilla auriculata, also known as 'Kokilaksha', is another herb with potential nephroprotective properties. It possesses antioxidant, anti-inflammatory, and anti-apoptotic effects, which have been shown to prevent drug-induced renal injury and preserve renal function in preclinical studies. The contributions of this review lie in the compilation and critical analysis of scientific evidence on the beneficial effects of Pedalium murex Linn and Hygrophilla auriculata in drug-induced nephrotoxicity. Furthermore, the review discusses the underlying mechanisms of action of these herbal remedies, shedding light on the pathways through which they exert their nephroprotective effects. The challenges associated with integrating herbal interventions into mainstream healthcare are also discussed, emphasizing the importance of further research to establish standardized protocols and assess potential interactions with conventional medications. Overall, this review provides valuable insights into the potential of these herbal remedies as adjunct treatments for drug-induced nephrotoxicity, while highlighting the need for cautious and evidence-based implementation in clinical practice.

Keywords

Drug-induced nephrotoxicity, Herbal interventions, Pedalium murex Linn, Hygrophilla auriculata, Nephroprotective effects

Conclusion

After reviewing the available literature, it can be concluded that Padalliu murex Linn and Hygrophilla auriculata may have potential for treating drug-induced nephrotoxicity. The phytochemical constituents of both plants have been shown to possess hepatoprotective and antioxidant properties, which could be beneficial for kidney function. Additionally, the diuretic potential of Hygrophilla Auriculata suggests that it may help to eliminate toxins from the body. However, it should be noted that further research is needed to establish the safety and efficacy of these plants in treating nephrotoxicity.

References

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How to cite this article

Riyazunnisa D., Kanala Somasekhar Reddy and Suggala V. Satyanarayana (2023). Herbal Interventions for Drug-Induced Nephrotoxicity: An Overview of Pedalium murex Linn and Hygrophilla auriculata. Biological Forum – An International Journal, 15(5a): 288-295.