Osteodystrophy in Chronic Renal Patients –A Study based on Bilaspur District, Chhattisgarh

Author: Seema Mishra and Shweta Tamrakar

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Abstract

As GFR loss progresses, disturbed mineral metabolism impairs bone microstructure and alters the bone remodelling process, known as CKD—mineral bone disease (MBD). CKD-MBD is characterized by (i) abnormal metabolism of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D; (ii) abnormalities in bone turnover, demineralization, segmental linear growth or strength; (iii) Soft-tissue calcification, either vascular or extra-osseous. Uremic vascular calcification and osteoporosis are the most common complications associated with CKD-MBD. Uncontrolled bone turnover by uremic toxins or secondary hyperparathyroidism leads to impaired bone mineralization and difficulty for calcium and inorganic phosphate to enter bone, resulting in elevated serum calcium and inorganic phosphate. In this study an attempt was made to study the bone health of CKD subjects. 25 CKD patients were studied; their biochemical parameters and bone health related parameters were assessed. The study confirmed that a complex relationship existed between chronic kidney disease-mineral and bone disorders (CKD-MBD) with adverse outcomes in non-dialysis and dialysis patients both. Thus, the study proved the prevalence of Osteodystrophy in CKD patients as a serious co-morbid condition.

Keywords

Bone resorption and remodelling, chronic kidney disease, Parathyroid hormone, Dyslipidemia

Conclusion

In conclusion, the mechanisms underlying bone loss and repeated fractures in CKD patients are complex and incompletely understood. In contrast to bone biopsy, currently available non-invasive diagnostic measures to detect both quantitative and qualitative bone loss are clinically inadequate as screening or diagnostic techniques. The further relevant researches should continue to investigate the detailed mechanisms of patho-physiology and should focus to seek targeted therapy for quality and quantity-related bone loss in CKD patients. Thus a complex relationship observed existed between chronic kidney disease and mineral and bone disorders (CKD-MBD) with adverse outcomes in non-dialysis and dialysis patients. This study proved the prevalence of Osteo-dystrophy in CKD patients as serious co-morbid condition.

References

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How to cite this article

Seema Mishra and Shweta Tamrakar (2023). Osteodestrophy in Chronic Renal Patients –A Study based on Bilaspur District, Chhattisgarh. Biological Forum – An International Journal, 15(6): 739-747.