Comparative Analysis of Bioactive compounds from Leaves Sample of Achyranthes aspera, their Pharmacological Studies, and their Importance in the Production of Silver Nanoparticles

Author: Gobind Prasad and Pallavi Praveen

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Abstract

Acyranthus aspera, commonly called as Prickly Chaff flower, is found in India and the Indian subcontinent and is also widely found in other subcontinents of Africa, America and Australia. These plants are considered to be invasive alien plants, weeds, and non-commercial plants. Scientific investigations on the medicinal potential of Acyranthus are limited due to a lack of knowledge on the traditional ethnobotanical importance of these plants. In this present study, bioactive chemicals from Acyranthus aspera have been isolated and characterized, opening the door for their possible use in a wide range of scientific fields. Additionally, studies on the potential Acyranthus aspera plant extracts have produced excellent results in pharmacological studies, with their constituents demonstrating strong antibacterial action against a variety of diseases. These extracts are also appealing candidates for usage in the nutraceutical and cosmeceutical sectors due to their antioxidant and anti-inflammatory effects. The extracts were rich in pharmaceutical important metabolites such as alkaloid, flavonoid, phenol, carbohydrate, amino acid, saponin, tannin, terpenoid, coumarin, etc. Higher flavonoid content (84.89±1.47 equivalent to mM of Quercetin) was found in Hydro-alcoholic leaf extract. The aqueous extracts contained higher Phenol content (121.89 ±1.39 equivalent to mM of Gallic acid) than Hydro-alcoholic leaf extract. The extracts possessed antimicrobial, antioxidant, and anti-inflammatory activity. Both aqueous and Hydro-alcohol extract had the potential for green synthesis of silver nanoparticles. The silver nano-particles thus produced have variable sizes that range from 20nm to 200nm. The current Invitro studies make them promising candidates for a safer alternative to chemical-based drugs for anti-microbial, anti-oxidant, and anti-inflammatory activities. The potential of plant extract for the greener synthesis of silver nanoparticles enables them alternatives to discover and design new integrated drug targeting and drug delivery system.

Keywords

Acyranthus aspera, Anti-inflammatory, Anti-oxidant, Anti-microbial, Flavonoids, Phenolics, Silver nanoparticles (AgNP)

Conclusion

Acyranthus aspera, a plant species rich in secondary metabolites, possesses immense potential across various scientific domains. Its widespread distribution in India, its ethnobotanical significance, and the diverse range of bioactive compounds the plant contains make it a compelling subject for further research. The exploration and utilization of plant extracts from Acyranthus aspera can contribute to the development of novel drugs, herbal remedies, and sustainable agricultural practices while providing unique solutions to the challenges faced in different industries.

References

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How to cite this article

Gobind Prasad and Pallavi Praveen (2023). Comparative Analysis of Bioactive compounds from Leaves Sample of Achyranthes aspera, their Pharmacological Studies, and their Importance in the Production of Silver Nanoparticles. Biological Forum – An International Journal, 15(5a): 388-397.