Synthesis, Characterization and Antioxidant Activity of 7, 8-Benzoflavone Derivatives

Author: Nahate N.R., Bhandarkar S.E. and Khobragade B.P.

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Abstract

Heterocyclic compounds are widely known for their medicinal properties. Flavonoids have gained significant attention due to their potent pharmacological behaviour. Flavones among them have been reported to be an important class of heterocyclic compounds possessing a wide range of biological activities. The synthesis of 7,8-benzoflavone derivatives can be challenging due to the complexity of the molecular structure. The precise manipulation of chemical reactions to achieve the desired substitutions at specific positions requires careful planning and optimization. In present work series of ten novel 7,8-benzoflavone have been synthesized by reported literature and tested for antioxidant potential. Structural analysis carried by FTIR, 1HNMR and GCMS. It was found that structural modification and substitution effects on the pharmacological potency. The primary objective of this study is to assess the impact of functional groups on the chemical behavior of benzoflavone derivatives. The present study shows that electron-donating groups exhibit better antioxidant potential and increase radical scavenging. This work introduces new 7,8-benzoflavone derivatives, expanding the chemical diversity of this class of compounds. This contributes to the pool of potential bioactive molecules for further exploration. Depending on the antioxidant activity observed, these novel derivatives might have potential applications in pharmaceuticals, nutraceuticals, or functional foods.

Keywords

Acylation, Esterification, 7,8-Benzoflavone, Antioxidant, Baker-Venkataraman rearrangement, Flavones

Conclusion

In the present work, we investigated that the benzo ring at the C-7 and C-8 positions of the flavone structure is a promising moiety that can synthesize compounds such as 7,8-benzoflavone derivatives that are likely to exhibit promising biological activities. Furthermore, the benzo ring inflection of the 7,8-benzoflavones structure intentionally incorporation of methoxy (OMe) and hydroxyl (-OH) group over the ring. Which enhances the strong biological activities.

References

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How to cite this article

Nahate N.R., Bhandarkar S.E. and Khobragade B.P. (2023). Synthesis, Characterization and Antioxidant Activity of 7, 8-Benzoflavone Derivatives. Biological Forum – An International Journal, 15(5a): 398-407.